Human Nutrition Research Center on Aging - Tufts University
- Role of sphingomyelin and its metabolites in increased vulnerability to oxidative stress in aging assessed in cell lines and in synaptosomes isolated from rodents.
- Neurotransmitter receptor properties that decrease resistance to oxidative stress and may account for the regional specificity of neuronal decline in aging.
- Signaling properties in kinase cascades and subsequent activation of transcription factors in cells exposed to oxidative stress and antioxidants.
- Role of monoamine oxidases in cellular dopamine toxicity.
- Effects of reduction of endogenous antioxidants, such as glutathione and dopamine exposure, on cognitive and motor behavior in the rodent.
- Effects of radiation- or oxygen-induced oxidative stress on accelerated brain aging and its retardation via intake of diets high in antioxidant fruits and vegetables.
- Influence of diets high in antioxidant fruits and vegetables on the retardation and reversal of age-related declines in motor and cognitive function, G protein- mediated signal transduction, and calcium regulation.
- Biophysical-lipid membrane interactions in aging and following oxidative stress.
- Oxidative stress effects on receptor internalization.
- Role of neuronal stimulation in subsequent protection against oxidative stress in cells.