Human Nutrition Research Center on Aging - Tufts University
- To identify and determine optimal levels of intake of nutrients from supplement or foods that can diminish risk for age-related cataract and macular degeneration in human cohorts.
- To develop algorithms for predicting risk for
- To elucidate pathophysiologic mechanisms that relate consuming higher glycemic index diets to increased risk of age related macular degeneration, cardiovascular disease and type 2 diabetes and cellular mechanisms to remove the glycatively induced damage. This involves discovering relationships between glycative stress, function of proteolytic machinery, and cytotoxicity.
- To identify other behavioral or physical parameters, i.e., obesity, insulinemia, which are related to risk for cataract and age-related macular degeneration.
- To elucidate aspects of the ubiquitin proteolytic pathway that regulate cell cycle and proliferation, lens differentiation (specifically cell denucleation), cell motility, and elicit inflammatory responses in the retina.
- Modeling age- or oxidation-related stress and find means to alleviate the stress in cell culture and animal experiments.
- To examine how nutritional factors alleviate age- or oxidation-related stress induced damage.
- To identify the mechanisms and roles of specific genes and/or proteins by which calorie restricted diets or lower glycemic index diets extend youthful function.
- To understand cellular ubiquitin dynamics by identifying changing ubiquitin conjugate patterns when different ubiquitins are expressed or cells are stressed.