Human Nutrition Research Center on Aging - Tufts University
- Using a variety of mouse models of colorectal cancer to identify the cell signaling pathways by which inadequate amounts of one-carbon nutrients (vitamins B2, B6, B12 and folate) enhance carcinogenesis. The Wnt signaling pathway is a particular focus of this laboratory.
- Utilizing both animal models of human polymorphisms, as well as observational studies in humans to identify how critical single nucleotide polymorphisms interact with one-carbon nutrients to further modulate the risk of cancer.
- Using a variety of mouse models of colorectal cancer to identify the cell signaling pathways by which obesity enhances carcinogenesis.
- Examining biopsies of the human colon in order to determine how the molecular and biochemical milieu of the obese individual differs from that of the lean individual.
- Using an innovative model of colorectal cancer in mice to examine the paradoxical cancer promoting effect of excess folic acid.
- Examining how modulation of one-carbon nutrient availability in the pregnant mouse modulates risk of colorectal cancer in the offspring.
- Utilizing both cell culture and animal experiments to determine how age and alcohol consumption modifies a variety of epigenetic features of DNA, and thereby affects cancer risk.