University of Southern California
|Research Focus||Metabolism of carotenoids to retinoids and retinoic acid; role of carotenoids in human vision; function of antioxidants; role of ß-carotene metabolites in breast cancer; role of ß-carotene and smoke in the development of lung cancer|
|Academic Appointments||Professor Emeritus, Department of Biochemistry, Tufts University School of Medicine|
|Selected Professional Affiliations||Chair, Dietary Reference Intakes Panel on Dietary Antioxidants and Related Compounds|
Featured HNRCA Research Publications
|Ferreira AL, Yeum KJ, Matsubara LS, Matsubara BB, Correa CR, Pereira EJ, Russell RM, Krinsky NI, Tang G. Doxorubicin as an antioxidant: maintenance of myocardial levels of lycopene under
doxorubicin treatment. Free Radical Biology & Medicine. 2007;43(5):740-51.
Ziouzenkova O, Orasanu G, Sukhova G, Lau E, Berger JP, Tang G, Krinsky NI, Dolnikowski GG, Plutzky J. Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses. Molecular Endocrinology. 2007;21(1):77-88.
Beretta G, Aldini G, Facino RM, Russell RM, Krinsky NI, Yeum KJ. Total antioxidant performance: a validated fluorescence assay for the measurement of plasma oxidizability. Analytical Biochemistry. 2006;354(2):290-8.
Hu KQ, Liu C, Ernst H, Krinsky NI, Russell RM, Wang XD. The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. Journal of Biological Chemistry. 2006;281(28):19327-38.
Zhao X, Aldini G, Johnson EJ, Rasmussen H, Kraemer K, Woolf H, Musaeus N, Krinsky NI, Russell RM, Yeum KJ. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. American Journal of Clinical Nutrition. 2006;83(1):163-9.
Other Recent Publications
Krinsky NI, Johnson EJ. Carotenoid actions and their relation to health and disease. Molecular Aspects of Medicine. 2005;26(6):459-516.
Tang G, Ferreira AL, Grusak MA, Qin J, Dolnikowski GG, Russell RM, Krinsky NI. Bioavailability of synthetic and biosynthetic deuterated lycopene in humans. Journal of Nutritional Biochemistry. 2005;16(4):229-35.
dos Anjos Ferreira AL, Yeum KJ, Russell RM, Krinsky NI, Tang G. Enzymatic and oxidative metabolites of lycopene. Journal of Nutritional Biochemistry. 2004;15(8):493-502.
Yeum KJ, Russell RM, Krinsky NI, Aldini G. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Archives of Biochemistry and Biophysics. 2004;430(1):97-103.
Prakash P, Liu C, Hu KQ, Krinsky NI, Russell RM, Wang XD. Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cells. Journal of Nutrition. 2004;134(3):667-73.
Krinsky NI. Human requirements for fat-soluble vitamins, and other things concerning these nutrients. Molecular Aspects of Medicine. 2003;24(6):317-24.
Ferreira AL, Yeum KJ, Russell RM, Krinsky NI, Tang G. Enzymatic and oxidative metabolites of lycopene. Journal of Nutritional Biochemistry. 2003;14(9):531-40.
Yeum KJ, Aldini G, Chung HY, Krinsky NI, Russell RM. The activities of antioxidant nutrients in human plasma depend on the localization of attacking radical species. Journal of Nutrition. 2003;133(8):2688-91.
Krinsky NI, Yeum KJ. Carotenoid-radical interactions. Biochemical and Biophysical Research Communications. 2003;305(3):754-60.
Krinsky NI, Landrum JT, Bone RA. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annual Review of Nutrition. 2003;23:171-201.
To see more of Dr. Norman Krinsky's publications, please visit PubMed and search for "Krinsky NI."