Nutrition and Cancer Biology Laboratory
Jean Mayer USDA HNRCA at Tufts University
711 Washington Street
Boston, MA 02111-1524
Phone: (617) 556-3174
Fax: (617) 556-3344
M.D., Harbin Medical University, China
M.P.H./MS, in Nutrition
|Research Focus||Carotenoids, retinoids, and carcinogenesis|
|Selected Professional Affiliations||American Association for Cancer Research|
|Board Certification||Medicine (China)|
Featured HNRCA Research Publications
Hu KQ, Liu C, Ernst H, Krinsky NI, Russell RM, Wang XD. The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. Journal of Biological Chemistry. 2006;281(28):19327-38.
Kim Y, Chongviriyaphan N, Liu C, Russell RM, Wang XD. Combined antioxidant (ß-carotene, a-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model. Carcinogenesis. 2006;27(7):1410-9.
Liu C, Russell RM, Wang XD. Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferatiion, and apoptosis in the gastric mucosa of ferrets. Journal of Nutrition. 2006;136(1):106-11.
Dudek EJ, Shang F, Liu C, Valverde P, Hobbs ML, Taylor A. Selectivity of the ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation diseases. FASEB Journal. 2005;19(12):1707-9.
Kim Y, Liu XS, Liu C, Smith DE, Russell RM, Wang XD. Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): A model for human lung cancer. Cancer Letters. 2005.
Other Recent Publications
Dan Z, Popov Y, Patsenker E, Preimel D, Liu C, Wang XD, Seitz HK, Schuppan D, Stickel F. Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential. FASEB Journal. 2005;19(7):845-847.
Liu C, Russell RM, Wang XD. Low dose beta-carotene supplementation of ferrets attenuates smoke-induced lung phosphorylations of jnk, p38 mapk, and p53 proteins. Journal of Nutrition. 2004;134 (10):2705-2710.
Prakash P, Liu C, Hu K, Krinsky NI, Russell RM, Wang XD. Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cells. Journal of Nutrition. 2004;134:667-673.
Liu C, Russell RM, Smith DEH, Bronson RT, Milbury PE, Furukawa S, Wang XD, Blumberg JB. The effect of dietary glutathione and coenzyme Q10 on the prevention and treatment of inflammatory bowel disease in mice. International Journal for Vitamin and Nutrition Research. 2004;74:74-85.
Liu C, Russell RM, Wang XD. Alpha-tocopherol and ascorbic acid decrease the production of beta-apo-carotenals and increase the formation of retinoids from beta-carotene in the lung tissues of cigarette smoke-exposed ferrets in vitro. Journal of Nutrition. 2004;134:426-30.
Liu C, Lian F, Smith DE, Russell RM, Wang X-D. Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. Cancer Research. 2003;63(12):3138-44.
Liu C, Russell RM, Wang XD. Exposing ferrets to cigarette smoke and a pharmacologival dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lung via induction of cytochrome p450 enzymes. Journal of Nutrition. 2003;133:173-9.
Liu C, Chung J, Seitz HK, Russell RM, Wang X-D. Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats. Alcoholism: Clinical and Experimental Research. 2002;26(11):1703-9.
Meshi B, Vitalis TZ, Ionescu D, Elliott WM, Liu C, Wang XD, Hayashi S, Hogg JC. Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response. Journal of Nutrition. 2002;26:52-7.
Chung J, Liu C, Smith D, Seitz HK, Russell RM, Wang X-D. Restoration of retinoic acid concentration suppresses ethanol-enhanced c-Jun expression and hepatocyte proliferation in rat liver. Carcinogenesis 2001;22(8):1213-9.
To see more of Dr. Chun Liu's publications, please visit PubMed and search for "Liu C."