2660: Meal effects on vitamin D absorption

Men and women, aged 50-69

To determine whether 25(OH)D3 response to vitamin D3 supplementation is affected by meal condition. (You may be selected to participate in one of three groups: fasting, low-fat meal, or high-fat meal.)
Major Exclusions	Liver disease, kidney disease, or gall bladder surgery Peptic ulcers, medications for heartburn or regular antacid use Use of calcium greater than 1000 mg per day Use of vitamin D greater than 400 IU per day Bariatric surgery, malabsorption Regular exposure to sunlight w/o sunscreen (>7hr/wk); use of tanning salon Allergy to egg Other health conditions and medications BMI less than 18.5 or greater than 27.9 kg/m2 . http://www.nhlbisupport.com/bmi/bmi-m.htm0
Length of Study	90 days	# of Visits	1 screening visit; 5 study visits (includes one 8:00 p.m. blood collection)
Residency	None	Study diet	If randomized to low-fat meal or high-fat meal groups, you will be given a breakfast meal on Days 1, 30, & 60. Meal consists of egg-bacon frittata with olive oil and vegetables, with Parmesan cheese topping, a slice of toast with either butter or jelly, and a mango milk smoothie (mango, milk, ginger ale, cream). If randomized to the fasting group, you will not receive a study meal but will fast for an additional 4 hours.	Supplement	Vitamin D3 (cholecalciferol), 50,000 IU capsule, one per month for 3 months.
Payment	$25 per screening visit; $220 for completion of study	Can I work?	Visit on Day 1 (approx. 7:00 a.m.) will take 2-3 hours. Visit on Day 1 (approx. 8 p.m.) will take approximately 30 minutes. The visit on day 30 will take approximately 1.5 hours and visits on days 60, and 90 will take approximately 1 hour. The morning visits on days 1, 30, 60, and 90 are 12-hr fasting visits

Length of study
Total length of the study including resident stays and nonresident visits.
This does not mean you will be testing the entire time.
Residency
The length of time volunteers are required to stay overnight at the HNRCA. Residents have their own private room, bathroom, television, VCR, and phone during their stay.
Payment
The amount of reimbursement for travel and inconvenience.
Number of visits
Total number of nonresident visits.
Study diet
Indicates meals which will be provided by the HNRCA
Can I work?
Indicates if you will be able to work and if so, when.

For more information please call 617-556-3068; please leave a message and we will return your call.

We appreciate your interest in our program and we hope to work with you in the future.

Thank you,

The Recruitment Office
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University