2730: Effect of dietary fat type and amount on vitamin D3 absorption

Men & women, ages 50 and older (Caucasian only at this time)

The purpose of the study is to determine whether vitamin D3 absorption is affected by different fatty acid profiles; specifically the presence of a meal with a high monounsaturated fatty acids (MUFA) to polyunsaturated fatty acids (PUFA) ratio vs. a meal with a low MUFA/PUFA ratio. You may be selected to participate in one of three groups: low-fat meal, high-fat meal or non-fat meal.
Major Exclusions	Liver or kidney disease (including a history of kidney stones) Use of lipid lowering medications Use of thiazides in doses greater than 37.5 mg per day BMI less than 20 or greater than 29.5 kg/m2 (calculate at link below)http://www.nhlbisupport.com/bmi/bmi-m.htm0 Use of calcium greater than 1000 mg per day Use of vitamin D greater than 400 IU per day Bariatric surgery, Crohn?s disease, malabsorption Regular exposure to sunlight w/o sunscreen (>7hr/wk); use of tanning salon Allergy to egg Other health conditions and medications
Length of Study	1 day	# of Visits	1 screening visit; 1 morning study visit (7:00 am) and 1 evening study visit (includes 6:00, 8:00 & 10:00 pm blood collections)
Residency	None	Study diet	For this study day, you will be asked to only eat the 3 meals that are given to you. You will be given a breakfast meal on the morning of the study visit to eat at the Center. You need to be able to refrain from eating or drinking anything for 4 hours after eating. You will be given a lunch meal to take home with you and you will return at 5:45 pm to eat your evening meal at the Center.	Supplement	Randomized to take either 1) Vitamin D3 (cholecalciferol), 50,000 IU capsule and 800 IU of deuterated vitamin D (non-radioactive tracer), or 2) 800 IU vitamin d3 and 800 IU of deuterated vitamin D (non-radioactive tracer).
Payment	$25 per screening visit; $150 for completion of study	Can I work?	The morning visit of the study day (7:00 a.m) will take approximately 2 hours. The evening visit (arrive at 5:45 p.m.) will require you to have dinner at the Center and to have three blood draws (6:00, 8:00, and 10:00 pm) which will take approximately 20 minutes each. You may leave and return between the evening blood draws, or you may stay here at the Center.

Length of study
Total length of the study including resident stays and nonresident visits.
This does not mean you will be testing the entire time.
Residency
The length of time volunteers are required to stay overnight at the HNRCA. Residents have their own private room, bathroom, television, VCR, and phone during their stay.
Payment
The amount of reimbursement for travel and inconvenience.
Number of visits
Total number of nonresident visits.
Study diet
Indicates meals which will be provided by the HNRCA
Can I work?
Indicates if you will be able to work and if so, when.

For more information please call 617-556-3068; please leave a message and we will return your call.

We appreciate your interest in our program and we hope to work with you in the future.

Thank you,

The Recruitment Office
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University