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Scientist II Vitamins and Carcinogenesis Laboratory Jean Mayer USDA HNRCA at Tufts University 711 Washington Street Boston, MA 02111-1524 Phone: (617) 556-3117 Fax: (617) 556-3234 E-mail: jimmy.crott@tufts.edu |
| Education | Ph.D., Physiology, Adelaide University, South Australia |
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| Research Focus | The effects of folate deficiency on patterns of gene expression and the identification of novel intracellular endpoints of folate deficiency that may be of relevance to cancer and other diseases of old age. |
Recent Publications |
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Liu Z, Brooks RS, Ciappio ED, Kim SJ, Crott JW, Bennett G, Greenberg AS, Mason JB. Diet-induced obesity elevates colonic TNF-alpha in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. J Nutr Biochem. 2011 Dec 29. [Epub ahead of print] Ciappio ED, Liu Z, Brooks RS, Mason JB, Bronson RT, Crott JW. Maternal B vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis in Apc1638N mouse offspring. Gut. 2011 Dec;60(12):1695-702. Ciappio ED, Mason JB, Crott JW. Maternal one-carbon nutrient intake and cancer risk in offspring. Nutr Rev. 2011 Oct;69(10):561-71. Huang T, Tucker KL, Lee YC, Crott JW, Parnell LD, Shen J, Smith CE, Ordovas JM, Li D, Lai CQ. Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population. Public Health Nutr. 2011 Oct;14(10):1805-12. Liu Z, Ciappio ED, Crott JW, Brooks RS, Nesvet J, Smith DE, Choi SW, Mason JB. Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice. FASEB J. 2011 Sep;25(9):3136-45. Ye X, Lai CQ, Crott JW, Troen AM, Ordovas JM, Tucker KL. The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. Psychosom Med. 2011 Jun;73(5):385-92. Huang T, Tucker KL, Lee YC, Crott JW, Parnell LD, Shen J, Smith CE, Ordovas JM, Li D, Lai CQ. Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in puerto rican adults. J Nutr. 2011 Apr 1;141(4):654-9. Bull CF, Beetstra-Hill S, Benassi-Evans BJ, Crott JW, Kimura M, Teo T, Wu J, Fenech MF. Application and adaptation of the in vitro micronucleus assay for the assessment of nutritional requirements of cells for DNA damage prevention. Mutagenesis. 2011 Jan;26(1):193-7. Chen CY, Crott J, Liu Z, Smith DE.Fructose and saturated fats predispose hyperinsulinemia in lean male rat offspring. Eur J Nutr. 2010 Sep;49(6):337-43. Lai CQ, Parnell LD, Troen AM, Shen J, Caouette H, Warodomwichit D, Lee YC, Crott JW, Qiu WQ, Rosenberg IH, Tucker KL, Ordovss JM. MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate. Am J Clin Nutr. 2010 May;91(5):1377-86. Chanson A, Parnell LD, Ciappio ED, Liu Z, Crott JW, Tucker KL, Mason JB. Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population. Am J Clin Nutr. 2009 Jun;89(6):1927-36. |
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