|Scientist I and Director
Obesity and Metabolism Laboratory
Jean Mayer USDA HNRCA at Tufts University
711 Washington Street
Boston, MA 02111-1524
Phone: (617) 556-3144
Fax: (617) 556-3224
|Education||M.D., New York University School of Medicine|
|Research Focus||Obesity, regulation of adipocyte metabolism, insulin resistance, systemic regulation|
|Academic Appointments||Assistant Professor, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University|
|Selected Professional Affiliations||American Diabetes Association
North American Association for the Study of Obesity
|Board Certification||Internal Medicine
Endocrinology and Metabolism
Liu Z, Brooks RS, Ciappio ED, Kim SJ, Crott JW, Bennett G, Greenberg AS, Mason JB. Diet-induced obesity elevates colonic TNF-alpha in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. J Nutr Biochem. 2011 Dec 29. [Epub ahead of print]
Greenberg AS, Kraemer FB, Soni KG, Jedrychowski MP, Yan QW, Graham CE, Bowman TA, Mansur A. Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis. EMBO J. 2011 Nov 2;30(21):4337-9.
Le KA, Mahurkar S, Alderete TL, Hasson RE, Adam TC, Kim JS, Beale E, Xie C, Greenberg AS, Allayee H, Goran MI. Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-kappaB stress pathway. Diabetes. 2011 Nov;60(11):2802-9.
Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MS, Puri V, Yan QW, Miyoshi H, Mashek DG. The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest. 2011 Jun;121(6):2102-10.
Perfield JW 2nd, Lee Y, Shulman GI, Samuel VT, Jurczak MJ, Chang E, Xie C, Tsichlis PN, Obin MS, Greenberg AS. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes. 2011 Apr;60(4):1168-76.
Kovsan J, Bl?her M, Tarnovscki T, Kl?ting N, Kirshtein B, Madar L, Shai I, Golan R, Harman-Boehm I, Sch?n MR, Greenberg AS, Elazar Z, Bashan N, Rudich A. Altered autophagy in human adipose tissues in obesity. J Clin Endocrinol Metab. 2011 Feb;96(2):E268-77.
Sawada T, Miyoshi H, Shimada K, Suzuki A, Okamatsu-Ogura Y, Perfield JW 2nd, Kondo T, Nagai S, Shimizu C, Yoshioka N, Greenberg AS, Kimura K, Koike T. Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype. PLoS One. 2010 Nov 16;5(11):e14006. Erratum in: PLoS One. 2010;5(11). doi: 10.1371/annotation/45438cdc-913a-4009-b2c1-5c1bc437c926.
Strissel KJ, DeFuria J, Shaul ME, Bennett G, Greenberg AS, Obin MS. T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice. Obesity (Silver Spring). 2010 Oct;18(10):1918-25.
Shaul ME, Bennett G, Strissel KJ, Greenberg AS, Obin MS. Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in mice. Diabetes. 2010 May;59(5):1171-81.
Miyoshi H, Souza SC, Endo M, Sawada T, Perfield JW 2nd, Shimizu C, Stancheva Z, Nagai S, Strissel KJ, Yoshioka N, Obin MS, Koike T, Greenberg AS.Perilipin overexpression in mice protects against diet-induced obesity. J Lipid Res. 2010 May;51(5):975-82.
Rogers NH, Perfield JW 2nd, Strissel KJ, Obin MS, Greenberg AS. Loss of ovarian function in mice results in abrogated skeletal muscle PPARdelta and FoxO1-mediated gene expression. Biochem Biophys Res Commun. 2010 Jan 29;392(1):1-3.
Danilova OV, Tai AK, Mele DA, Beinborn M, Leiter AB, Greenberg AS, Perfield JW 2nd, Defuria J, Singru PS, Lechan RM, Huber BT. Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity. Endocrinology. 2009 Dec;150(12):5240-8.
DeFuria J, Bennett G, Strissel KJ, Perfield JW 2nd, Milbury PE, Greenberg AS, Obin MS. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J Nutr. 2009 Aug;139(8):1510-6.
Rogers NH, Witczak CA, Hirshman MF, Goodyear LJ, Greenberg AS. Estradiol stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus. Biochem Biophys Res Commun. 2009 May 15;382(4):646-50.
Rogers NH, Perfield JW 2nd, Strissel KJ, Obin MS, Greenberg AS. Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity. Endocrinology. 2009 May;150(5):2161-8.