|Senior Scientist and Director
Laboratory for Nutrition and Vision Research
Jean Mayer USDA HNRCA at Tufts University
711 Washington Street
Boston, MA 02111-1524
Phone: (617) 556-3156
Fax: (617) 556-3132
|Education||Ph.D., Organic Chemistry
|Research Focus||Research focus: the role of the ubiquitin pathway in the regulation of cell proliferation, differentiation and protein quality in the lens and retina.|
|Academic Appointments||Professor, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University
Professor, Biochemistry, Sackler School of Graduate Biomedical Sciences
Associate Professor, Ophthalmology, Tufts University School of Medicine
|Selected Professional Affiliations||Senior Fullbright Fellow
Denham Harmon Award for Excellence in Aging Research
Osborn and Mendel Award for Excellence in Nutrition Research
Weikel KA, Fitzgerald P, Shang F, Caceres MA, Bian Q, Handa JT, Stitt AW, Taylor A. Natural History of Age-Related Retinal Lesions That Precede AMD in Mice Fed High or Low Glycemic Index Diets. Invest Ophthalmol Vis Sci. 2012 Feb 2;53(2):622-32.
Uchiki T, Weikel KA, Jiao W, Shang F, Caceres A, Pawlak D, Handa JT, Brownlee M, Nagaraj R, Taylor A. Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics). Aging Cell. 2012 Feb;11(1):1-13.
Shang F, Taylor A. Ubiquitin-proteasome pathway and cellular responses to oxidative stress. Free Radic Biol Med. 2011 Jul 1;51(1):5-16.
Bento CF, Fernandes R, Ramalho J, Marques C, Shang F, Taylor A, Pereira P. The chaperone-dependent ubiquitin ligase CHIP targets HIF-1alpha for degradation in the presence of methylglyoxal. PLoS One. 2010 Nov 29;5(11):e15062.
Caceres A, Shang F, Wawrousek E, Liu Q, Avidan O, Cvekl A, Yang Y, Haririnia A, Storaska A, Fushman D, Kuszak J, Dudek E, Smith D, Taylor A. Perturbing the ubiquitin pathway reveals how mitosis is hijacked to denucleate and regulate cell proliferation and differentiation in vivo. PLoS One. 2010 Oct 20;5(10):e13331.
Dudek EJ, Lampi KJ, Lampi JA, Shang F, King J, Wang Y, Taylor A. Ubiquitin proteasome pathway-mediated degradation of proteins: effects due to site-specific substrate deamidation. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4164-73.
Whitcomb EA, Taylor A.Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH7. Cell Div. 2009 Aug 7;4:17.