Fu Shang, Ph.D.

	Scientist I Laboratory for Nutrition and Vision Research Jean Mayer USDA HNRCA at Tufts University 711 Washington Street Boston, MA 02111-1524 Phone: (617) 556-3158 Fax: (617) 556-3132 E-mail: fu.shang@tufts.edu
Education	Ph.D., Biochemistry Beijing Medical University
Research Focus	Effects of nutrition, oxidation, and aging on protein turnover in the lens; lens development and differentiation; developing models of age-and diabetes-related cataract
Selected Professional Affiliations	The Association for Research in Vision and Ophthalmology American Society for Mass Spectrometry Board
Recent Publications
Weikel KA, Fitzgerald P, Shang F, Caceres MA, Bian Q, Handa JT, Stitt AW, Taylor A. Natural History of Age-Related Retinal Lesions That Precede AMD in Mice Fed High or Low Glycemic Index Diets. Invest Ophthalmol Vis Sci. 2012 Feb 2;53(2):622-32. Uchiki T, Weikel KA, Jiao W, Shang F, Caceres A, Pawlak D, Handa JT, Brownlee M, Nagaraj R, Taylor A. Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics). Aging Cell. 2012 Feb;11(1):1-13. Shang F, Taylor A. Ubiquitin-proteasome pathway and cellular responses to oxidative stress. Free Radic Biol Med. 2011 Jul 1;51(1):5-16. Bento CF, Fernandes R, Ramalho J, Marques C, Shang F, Taylor A, Pereira P. The chaperone-dependent ubiquitin ligase CHIP targets HIF-1? for degradation in the presence of methylglyoxal. PLoS One. Caceres A, Shang F, Wawrousek E, Liu Q, Avidan O, Cvekl A, Yang Y, Haririnia A, Storaska A, Fushman D, Kuszak J, Dudek E, Smith D, Taylor A. Perturbing the ubiquitin pathway reveals how mitosis is hijacked to denucleate and regulate cell proliferation and differentiation in vivo. PLoS One. 2010 Oct 20;5(10):e13331. Dudek EJ, Lampi KJ, Lampi JA, Shang F, King J, Wang Y, Taylor A. Ubiquitin proteasome pathway-mediated degradation of proteins: effects due to site-specific substrate deamidation. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4164-73.