BIOCHEMISTRY 000:
QUALIFYING EXAM (O CR)
Students present and defend a proposal for research consisting of a
statement of an original research problem in which a scientific
question is asked and the experimental approach to answering the
question is explained in a written proposal. The proposal is presented
orally to the faculty. Program faculty
BIOCHEMISTRY 210: PRINCIPLES OF
BIOCHEMISTRY (1 CR)
A general survey of the structure, function, and interrelationships of
the molecules involved in the life processes, primarily for medical
students. Relationships to disease are emphasized. Baleja, program
faculty
BIOCHEMISTRY 223: GRADUATE
BIOCHEMISTRY (2 CR)
A graduate-level discussion of the structure and function of
biologically important molecules. Problems of protein and nucleic acid
biochemistry are emphasized. Schaffhausen, program faculty
BIOCHEMISTRY 230: BIOCHEMISTRY
OF GENE EXPRESSION AND SIGNAL TRANSDUCTION (2 CR)
The molecular mechanisms of gene expression and signal transduction.
The fundamental mechanisms underlying transcription, RNA processing,
translation, and DNA replication are highlighted, and the integration
of these fundamental mechanisms into molecular and cellular regulation
of proliferation and signal transduction is discussed. Current
literature is emphasized. Yee, program faculty
BIOCHEMISTRY 230A: BIOCHEMISTRY
OF GENE EXPRESSION (1 CR)
The fundamental mechanisms underlying transcription, RNA processing,
translation, and DNA replication are highlighted. Current literature is
emphasized. Yee, program faculty
BIOCHEMISTRY 230B: BIOCHEMISTRY
OF SIGNAL TRANSDUCTION (1 CR)
The integration of these fundamental mechanisms into molecular and
cellular regulation of proliferation and signal transduction is
discussed. Current literature is emphasized. Yee, program faculty
BIOCHEMISTRY 231:
MOLECULAR RECOGNITION IN BIOLOGY and DRUG DESIGN (1 CR)
Discussion of the association of biological molecules. Complexes of proteins with other proteins,
with lipids, and with nucleic acids are emphasized. A discussion of drug screening and
optimization techniques as they have been applied in a number of detailed, real-world cases.
Bachovchin, Bohm, and program faculty
BIOCHEMISTRY 231A:
MOLECULAR RECOGNITION IN BIOLOGY (0.5 CR)
Discussion of the association of biological molecules. Complexes of proteins with other proteins,
with lipids, and with nucleic acids are emphasized. Bohm, program faculty
BIOCHEMISTRY 231B:
DRUG DESIGN (0.5 CR)
A discussion of drug screening and optimization techniques as they have been applied in
a number of detailed, real-world cases. This course builds on the concepts discussed in Biochemistry 231A,
which is a prerequisite. Bachovchin, program faculty
BIOCHEMISTRY 235:
FUNDAMENTALS OF NUCLEAR MAGNETIC RESONANCE (0.5 CR)
Fundamentals of NMR is a course designed to learn advanced topics in NMR spectroscopy at
a deep and fundamental level. Baleja
BIOCHEMISTRY 275: APPLIED ETHICS FOR SCIENTISTS (0.5 CR)
A series of discussions, with active student participation, in definition and evaluation of both positive and problematic ethical issues in research. Issues considered include: ethical underpinnings of science; recognition, reporting, and evaluation of apparent misconduct; authorship, credit, and intellectual property; conflict of interest in reviews of papers, grants, and in commerce; animals and humans as subjects in research; and ethical choice of research projects. Program faculty
BIOCHEMISTRY 291, 292: GRADUATE
SEMINAR (0.5 CR)
Presentations of scientific research by visiting speakers from the
Boston community and beyond. Program faculty
BIOCHEMISTRY 293, 294: SPECIAL
TOPICS (0.5 CR)
Advanced seminars. Topics have included protein phosphorylation, G
protein function, and molecular structure determination by NMR.
Students may also pursue guided individual study of an approved topic.
Program faculty
BIOCHEMISTRY 295, 296: JOURNAL
CLUB (0.5 CR)
Presentation of individual reports on literature topics to a seminar
group for discussion. Program faculty
BIOCHEMISTRY 297, 298, 299:
GRADUATE RESEARCH (ARRANGED CR)
Guided research on a topic suitable for a doctoral dissertation.
Program faculty
BIOCHEMISTRY 403, 404: PHD
DEGREE ONLY (0 CR)
Doctoral dissertation preparation. Program faculty
SACKLER 202:
STRUCTURAL BIOLOGY ( 0.5 CR)
Intensive summer course covering the basic theory and practice of
macromolecular crystallography and NMR. Roughly one week is devoted to
each technique, and the course meets from 9am-5pm daily. Bohm and Baleja