BIOCHEMISTRY 000:
QUALIFYING EXAM (O CR)
Students present and defend a proposal for research consisting of a
statement of an original research problem in which a scientific
question is asked and the experimental approach to answering the
question is explained in a written proposal. The proposal is presented
orally to the faculty. Program faculty
BIOCHEMISTRY 210: PRINCIPLES OF
BIOCHEMISTRY (1 CR)
A general survey of the structure, function, and interrelationships of
the molecules involved in the life processes, primarily for medical
students. Relationships to disease are emphasized. Baleja, program
faculty
BIOCHEMISTRY 216:
IMMUNOCHEMISTRY (1 CR)
(Cross-listed as IMMUNOLOGY 227) Structures of antigens, antibodies,
and immunologically important cell surface molecules (B-cell and T-cell
receptors, adhesion molecules); affinities of interaction; cloning,
expression, and genetic modification of recombinant antibody domains;
catalytic antibodies; and applications of immunochemical techniques in
biochemical research. Stollar, Brodeur
BIOCHEMISTRY 223: GRADUATE
BIOCHEMISTRY (2 CR)
A graduate-level discussion of the structure and function of
biologically important molecules. Problems of protein and nucleic acid
biochemistry are emphasized. Schaffhausen, program faculty
BIOCHEMISTRY 227A: MOLECULAR
RECOGNITION IN BIOLOGY (0.5 CR)
Discussion of the association of biological molecules. Complexes of
proteins with other proteins, with lipids, and with nucleic acids are
emphasized. Bohm, program faculty
BIOCHEMISTRY
227B: DRUG DESIGN (0.5 CR)
A discussion of drug screening and optimization techniques as they have been applied in a number of detailed, real-world cases. This course builds on the concepts discussed in Biochemistry 227A, which is a prerequisite. Bachovchin, program faculty
BIOCHEMISTRY 230: BIOCHEMISTRY
OF GENE EXPRESSION AND SIGNAL TRANSDUCTION (2 CR)
The molecular mechanisms of gene expression and signal transduction.
The fundamental mechanisms underlying transcription, RNA processing,
translation, and DNA replication are highlighted, and the integration
of these fundamental mechanisms into molecular and cellular regulation
of proliferation and signal transduction is discussed. Current
literature is emphasized. Yee, program faculty
BIOCHEMISTRY 230A: BIOCHEMISTRY
OF GENE EXPRESSION (1 CR)
The fundamental mechanisms underlying transcription, RNA processing,
translation, and DNA replication are highlighted. Current literature is
emphasized. Yee, program faculty
BIOCHEMISTRY 230B: BIOCHEMISTRY
OF SIGNAL TRANSDUCTION (1 CR)
The integration of these fundamental mechanisms into molecular and
cellular regulation of proliferation and signal transduction is
discussed. Current literature is emphasized. Yee, program faculty
BIOCHEMISTRY 234:
MACROMOLECULAR CRYSTALLOGRAPHY (0.5 CR)
This course is an introduction to practical macromolecular
crystallography. It includes some theoretical material but emphasizes
the practical aspects of the technique. Students will grow protein
crystals and use them to learn crystallographic data collection,
phasing, and molecular replacement methods. Bohm
BIOCHEMISTRY 275: APPLIED ETHICS FOR SCIENTISTS (0.5 CR)
A series of discussions, with active student participation, in definition and evaluation of both positive and problematic ethical issues in research. Issues considered include: ethical underpinnings of science; recognition, reporting, and evaluation of apparent misconduct; authorship, credit, and intellectual property; conflict of interest in reviews of papers, grants, and in commerce; animals and humans as subjects in research; and ethical choice of research projects. Program faculty
BIOCHEMISTRY 291, 292: GRADUATE
SEMINAR (0.5 CR)
Presentations of scientific research by visiting speakers from the
Boston community and beyond. Program faculty.
BIOCHEMISTRY 293, 294: SPECIAL
TOPICS (0.5 CR)
Advanced seminars. Topics have included protein phosphorylation, G
protein function, and molecular structure determination by NMR.
Students may also pursue guided individual study of an approved topic.
Program faculty.
BIOCHEMISTRY 295, 296: JOURNAL
CLUB (0.5 CR)
Presentation of individual reports on literature topics to a seminar
group for discussion. Program faculty.
BIOCHEMISTRY 297, 298, 299:
GRADUATE RESEARCH (ARRANGED CR)
Guided research on a topic suitable for a doctoral dissertation.
Program faculty
BIOCHEMISTRY 403, 404: PHD
DEGREE ONLY (0 CR)
Doctoral dissertation preparation. Program faculty