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Norman I. Krinsky

M&V 624
136 Harrison Ave.
Boston, MA 02111
norman.krinsky@tufts.edu

office: 617-636-6861

Norman Krinsky, Ph.D.

Professor Emeritus, Tufts Department of Biochemistry

Scientist, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University

 

Links:

Research

Lab Members

Recent Publications

  

Research Summary:

Metabolism of carotenoids to retinoids and retinoic acid. Role of carotenoids in human vision. Function of antioxidants. Role of ß-carotene metabolites in breast cancer; role of ß-carotene and smoke in the development of lung cancer.

Research:


 

For more details, please see the publications below.

Lab Members

Alumni

Recent Publications

  1. Krinsky, Norman I; Johnson, Elizabeth J. (2005). “Carotenoid action and their relation to health and disease.” Molecular Aspects of Medicine 26(6): 459-516
  2. Zhao, Xiafeng; Aldini, Giancarlo; Johnson, Elizabeth J; Rasmussen, Helen; Kraemer, Klaus; Woolf, Herb; Musaeus, Nina; Krinsky, Norman I; Russell, Robert M; Yeum, Kyung-Jin. (2006). “Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women.” American Journal of Clinical Nutrition 83(1): 163-169
  3. Hu, Kang-Quan; Liu, Chun; Ernst, Hansgeorg; Krinsky, Norman I; Russell, Robert M; Wang, Xiang-Dong. (2006). “The Biochemical Characterization of Ferret Carotene-9’,10’-monooxygenase Catalyzing Cleavage of Carotenoids in vitro and in vivo.” Journal of Biological Chemistry 2006, May 6; [Epub ahead of print]
  4. Beretta, G., Aldini, G., Facino, R.M., Russell, R.M., Krinsky, N.I. and Yeum, K.-J. (2006). “Total Antioxidant Performance (TAP): A Validated Fluorescent Assay for the Measurement of Lipid-compartment plasma oxidizability.” Analytical Biochemistry, in press
  5. Tang, G., Ferreira, A.L.A., Grusak, M.A., Qin, J., Dolnikowski, G.G., Russell, R.M. and Krinsky, N.I. (2006). “Absorption and Metabolism of Synthetic and Biosynthetic Deuterated Lycopene in Humans.” Journal of Nutritional Biochemistry, in press
  6. Yeum, K.-J., Aldini, G., Johnson, E.J., Russell, R.M. and Krinsky, N.I. in CAROTENOIDS AND RETINOIDS, L. Packer, U. Obermller-Jevic, K.. Kraemer and H. Sies, eds., AOCS Press, Champaign, IL, pp. 218-228 (2005) Effect of Feeding and the Depleting a High Fruit and Vegetable Diet on Oxidizability in Human Serum
  7. Krinsky, N.I. in CAROTENOIDS AND RETINOIDS, L. Packer, U. Obermller-Jevic, K.. Kraemer and H. Sies, eds., AOCS Press, Champaign, IL, pp. 338-344 (2005) Safety of -Carotene
  8. Tang, G., Ferreira, A.L.A., Grusak, M.A., Qin, J., Dolnikowski, G.G., Russell, R.M. and Krinsky, N.I. J. Nutr. Biochem. 16: 229-235 (2005) Bioavailability of Synthetic and Biosynthetic Deuterated Lycopene in Humans
  9. Krinsky, N.I. SIGHT AND LIFE Newsletter 2:10-15 (2005) The Biological Activity of Carotenoid Metabolites
  10. Krinsky, N.I., Guest Editor, Proceedings of Symposium to Honor the Memory of James Allen Olson: Functions and Actions of Retinoids and Carotenoids: Building on the Vision of James Allen Olson J. Nutr. 134 (Suppl 1S) 218S-293S (2004)
  11. Krinsky, N.I., Forward, Symposium to Honor the Memory of James Allen Olson, J. Nutr. 134 (Suppl. 1S) 220s (2004)
  12. Prakash, P., Liu, C., Hu, K.-Q., Krinsky, N.I., Russell, R.M. and Wang, X.-D. J. Nutr. 134:667-673 (2004)
    Effects of -Carotene, -Apo-14'-carotenoic Acid and Benzo[a]pyrene on Retinoic Acid Receptor Expression and Growth of Normal Human Bronchial Epithelial Cells.
  13. Yeum, K.-Y., Russell, R.M., Krinsky, N.I. and Aldini, G. Archives of Biochemistry and Biophysics 430:97-103 (2004) Biomarkers of Antioxidant Capacity in the Hydrophilic and Lipophilic Compartments of Human Plasma
  14. Krinsky, N.I., Mayne, S.T. and Sies, H. in CAROTENOIDS IN HEALTH AND DISEASE (Krinsky, N.I., Mayne, S.T. and Sies, H. eds.), Marcel Dekker, New York, pp. 547-551 (2004) Carotenoids: Looking Forward
  15. Krinsky, N.I., Mayne, S.T. and Sies, H. (eds) CAROTENOIDS IN HEALTH AND DISEASE, Marcel Dekker, New York, pp. 1-568 (2004)
  16. Ferreira, A.L.A., Yeum, K.-Y., Russell, R.M., Krinsky, N,I, and Tang, G. J. Nutr. Biochem. 15:493-502 (2004) (Corrected version of J. Nutr. Biochem. 14: 531-540 (2003)) Enzymatic and Oxidative Metabolites of Lycopene
  17. Krinsky, N.I in CRITICAL REVIEWS OF OXIDATIVE STRESS AND AGING: ADVANCES IN BASIC SCIENCE, DIAGNOSTICS, AND INTERVENTION (R .G. Cutler and H. Rodriguez, Eds.) World Scientific Publishing Co., New Jersey pp. 598-611, (2003) Carotenoids and Oxidative Stress
  18. Aldini, G., Yeum, KJ., Carini, M., Krinsky, N.I. and Russell, R.M. Biochem Biophys Res Commun 302: 413-418 (2003) (-)-Epigallocatechin-(3)-gallate Spares Carotenoids, Recycles ?-Tocopherol and Prevents Oxidative Damage in Both the Aqueous and Lipid Compartments of Human Plasma
  19. Aldini, G., Yeum, KJ., Russell, R.M. and Krinsky, N.I. Nutritional Sciences 6: 12-19 (2003) A Selective Assay to Measure Antioxidant Capacity in Both the Aqueous and Lipid Compartments of Plasma
  20. Krinsky, NI and Yeum, K-J. Biochem. Biophys. Res. Commun. 305:754-760 (2003) Carotenoid-Radical Interactions
  21. Krinsky, NI, Landrum, JT and Bone RA. Annu. Rev. Nutr. 23: 171-201 (2003) Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye
  22. Yeum, K.-J., Aldini, G., Chung, H.-Y., Krinsky, N.I. and Russell, R.M. J Nutr. 133: 2688-2691 (2003)
    The Activities of Antioxidant Nutrients in Human Plasma Depend on the Localization of Attacking Radical Species
  23. Ferreira, A.L.A., Yeum, K.-Y., Russell, R.M., Krinsky, N,I, and Tang, G. J. Nutr. Biochem. 14: 531-540 (2003) (Corrected version appears as J. Nutr. Biochem. 15:493-502 (2004) Enzymatic and Oxidative Metabolites of Lycopene
  24. Krinsky, NI. Molecular Aspects of Medicine 24:317-324 (2003) Human Requirements for Fat-soluble Vitamins, and Other Things Concerning These Nutrients
  25. Krinsky, N.I. J. Nutrition 132:540S-542S (2002) Possible biological mechanisms for a protective role of xanthophylls
  26. Tibaduiza, E.C., Fleet, J.C., Russell, R.M., and Krinsky, N.I. J. Nutrition 132:1368-1375 (2002) Excentric Cleavage Products of -Carotene Inhibit Estrogen Receptor Positive and Negative Breast Tumor Cell Growth in Vitro and Inhibit Activator Protein-1-Mediated Transcriptional Activation

             

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