Research Studies
Research Studies of the Nutrition/Infection Unit are conducted at the Tufts Medical Center in Boston, Massachusetts.
 Many of our research services are supported by the Centers for AIDS Research (CFAR), an NIH-funded collaboration among Lifespan hospitals and Tufts and Brown Universities. Its purpose is to encourage HIV-related collaboration between the institutions, to fund and engage investigators beginning HIV research, to provide HIV research forums and education, and to make available services which assist HIV research efforts.
Our observational studies include:
150L SUBSTITUTION – to find out the pattern of resistance mutations, including the 150L substitution, in patients who have failed an atazanavir-containing regimen
BIENESTAR – to examine the role of illicit drug use on nutritional status and outcomes, including antioxidant status, oxidative stress and liver dysfunction, in Hispanic, HIV-positive and HIV-negative, drug users and non-drug users – conducted in Spanish
CARE – to examine the risk of heart disease in HIV-infected individuals
CYTOCHROME – to investigate the effect of medications on a major liver enzyme
FRAM 2 – to investigate heart disease risk, body fat distribution, and how the body uses fats and sugars in HIV-infected people. This is a follow-up of FRAM 1, a multi-site study of nearly 1,200 patients.
Our intervention studies are:
DIET – to examine in patients with elevated triglycerides the effect of a diet intervention that is high in omega-3 fatty acids and fiber and low in glycemic index on the metabolic changes associated with HIV lipodystrophy
KALETRA MONOTHERAPY – to determine whether taking Kaletra as a single anti-HIV drug will provide an effective regimen with few side effects
SWITCH - to investigate an antiretroviral drug switch intervention for fat atrophy
TH9507 - to determine if TH9507 is effective and safe at reducing visceral adipose
tissue (excess abdominal fat) in people with HIV-associated adipose redistribution syndrome (HARS).
Privacy and confidentiality are strictly maintained.
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