Lecture 6

Gary Sahagian - Trafficking to Lysosomes & Plasma Membrane

Background reading for Lectures 5-7:

Alberts, Chapter 13 (all sections not already assigned).

Articles to read for Lecture 6:

Rohn, W.M., Rouille', Y., Waguri, S., Hoflack, B. (2000) “Bi-directional trafficking between the trans-Golgi network and the endosomal/lysosomal system”, Journal of Cell Science 113, 2093-2101

LysoTraffickReview.pdf

Other Lecture 6 articles (for reference only):

Reviews:

  1. Seglen, P.O. and Bohley (1992) "Autophagy and Other Vacuolar Protein Degradation Mechanisms", Experientia 48, 158-172.

  2. Kornfeld, S. (1992) "Structure and Function of the Mannose 6-Phosphate/Insulin-Like Growth Factor II Receptor", Annu. Rev. Biochem. 61, 307-330.

  3. Ludwig, T., Le Borgne, R.., and Hoflack, B. (1995) “Roles for Mannose 6-Phosphate Receptors in Lysosomal Enzyme Sorting, IGF-II Binding and Clathrin-coat Assembly”, TICB 5, 202-205.

  4. Hunziker, W. and Geuze, H.J. (1995) “Intracellular Trafficking of Lysosomal Membrane Proteins”, BioEssays 18, 379-389.

  5. Simons, K. and Wandinger-Ness, A. (1990) "Polarized Sorting in Epithelia" Cell 62, 207-210.

  6. Almers, W. (1990) "Exocytosis", Ann. Rev. Physiol. 52, 607-624.

  7. Huttner, W.B., Gerdes, H-H. and Rosa, P. (1991) "The Granin (Chromogranin / Secretogranin) Family", TIBS 16, 27-30.

  8. Lisanti, M.P. and Rodriguez-Boulan, E. (1990) "Glycophospholipid Membrane Anchoring Provides Clues to the Mechanism of Protein Sorting in Polarized Epithelial Cells", TIBS 15, 113-118.

  9. Hopkins, C.R. (1991) "Polarity Signals", Cell 66, 827-829.

  10. Mostov, K., Apodaca, G., Aroeti, B. and Okamoto, C. (1992) "Plasma Membrane Protein Sorting in Polarized Epithelial Cells", J. Cell Biol. 116, 577-583.

  11. Monck, J.R. and Fernandez, J.M. (1992) "The Exocytic Fusion Pore", J. Cell Biol. 119, 1395-1404.

  12. Wollner, D.A. and Nelson, W.J. (1992) "Establishing and Maintaining Epithelial Cell Polarity: Roles of Protein Sorting, Delivery and Retention", J. Cell Science 102, 185-190.

  13. Kirchhausen, T., Bonifacino, J.S. and Riezman (1997) “Linking Cargo to Vesicle Formation: Receptor Tail Interactions”, Curr. Opin. Cell Biol. 9, 488-495.

Original Research Articles:

  1. Hickman, S. and Neufeld, E.F. (1972) "A Hypothesis for I-Cell Disease: Defective Hydrolases that Do Not Enter Lysosomes", Biochem. Biophys. Res. Commun. 49, 992-999.

  2. Natowicz, M.R., Chi, M.M.-Y., Lowry, O.H. and Sly, W.S. (1979) "Enzymatic Identification of Mannose 6-Phosphate on the Recognition Marker for Receptor-Mediated Pinocytosis of Glucuronidase by Human Fibroblasts", Proc. Natl. Acad. Sci. USA 76, 4322-4326.

  3. Sahagian, G.G., Distler, J. and Jourdian, G.W. (1981) "Characterization of a Membrane-Associated Receptor from Bovine Liver that Binds Phosphomannosyl Residues of Bovine Testicular Galactosidase", Proc. Natl. Acad. Sci. USA 78, 4289-4293.

  4. Hoflack, B. and Kornfeld, S. (1985) "Purification and Characterization of a Cation-Dependent Mannose 6-Phosphate Receptor from Murine P388D1 Macrophages and Bovine Liver", J. Cell. Biol. 260, 12008-12014.

  5. Lobel, P., Dahms, N.M. and Kornfeld, S. (1988) "Cloning and Sequence Analysis of the Cation-Independent Mannose 6-Phosphate Receptor", J. Biol. Chem. 263, 2563-2570.

  6. Dahms, N.M., Lobel, P., Breitmeyer, J., Chirgwin, J.M. and Kornfeld, S. (1987) "46 kD Mannose 6-Phosphate Receptor: Cloning, Expression, and Homology to the 215 kD Mannose 6-Phosphate Receptor", Cell 50, 181-192.

  7. Stein, M., Zijderhand-Bleekemolen, J.E., Geuze, H., Hasilik, A. and von Figura, K. (1987) "Mr 46,000 Mannose 6-Phosphate Specific Receptor: Its Role in Targeting of Lysosomal Enzymes", EMBO J. 6, 2677-2681.

  8. Baranski, T.J., Faust, P.L. and Kornfeld, S. (1990) "Generation of a Lysosomal Enzyme Targeting Signal in the Secretory Protein Pepsinogen", Cell 63, 281-291.

  9. Cuozzo, J., Tao, K., Cygler, M. and Sahagian, G.G. (1998) “Lysine-based structure responsible for selective mannose phosphorylation of cathepsin D and cathepsin L defines a common structural motif for lysosomal enzyme targeting”, J. Biol. Chem. 273, 21067-21076.

  10. Brown, W.J. and Farquhar, M.G. (1984) "The Mannose 6-Phosphate Receptor for Lysosomal Enzymes Is Concentrated in Cis Golgi Cisternae", Cell 36, 295-307.

  11. Sahagian, G.G. (1984) "The Mannose 6-Phosphate Receptor: Function, Biosynthesis and Translocation", Biol. Cell. 51, 207-214.

  12. Brown, W.J., Goodhouse, J. and Farquhar, M.G. (1986) "Mannose 6-Phosphate Receptors for Lysosomal Enzymes Cycle Between the Golgi Complex and Endosomes", J. Cell. Biol. 103, 1235-1247.

  13. Ludwig, T., Griffiths, G. and Hoflack, B. (1991) "Distribution of Newly Synthesized Lysosomal Enzymes in the Endocytic Pathway of Normal Rat Kidney Cells", J. Cell Biol. 115, 1561-1572.

  14. Lobel, P., Fujimoto, K., Ye, R.D., Griffiths, G. and Kornfeld, S. (1989) "Mutations in the Cytoplasmic Domain of the 275 kD Mannose 6-Phosphate Receptor Differentially Alter Lysosomal Enzyme Sorting and Endocytosis", Cell 57, 787-796.

  15. Pearse, B.M.F. (1988) "Receptors Compete for Adaptors Found in Plasma Membrane Coated Pits", EMBO J. 7, 3331-3336.

  16. Glickman, J.N., Conibear, E. and Pearse, B.M.F. (1989) "Specificity of Binding of Clathrin Adaptors to Signals on the Mannose 6-Phosphate/Insulin-Like Growth Factor II Receptor", EMBO J. 8, 1041-1047.

  17.  Westlund, B., Dahms, N.M. and Kornfeld, S. (1991) "The Bovine Mannose 6-Phosphate/Insulin-Like Growth Factor II Receptor: Localization of Mannose 6-Phosphate Binding Sites to Domains 1-3 and 7-11 of the Extracytoplasmic Region", J. Biol. Chem. 266, 23233-23239.

  18. Canfield, W.M., Johnson, K.F., Ye, R.D., Gregory, W. and Kornfeld, S. (1991) "Localization of the Signal for Rapid Internalization of the Bovine Cation-Independent Mannose 6-Phosphate /Insulin-Like Growth Factor II Receptor to Amino Acids 24-29 of the Cytoplasmic Tail", J. Biol. Chem. 266, 5682-5688.

  19. Jadot, M., Canfield, W.M., Gregory, W. and Kornfeld, S. (1992) "Characterization of the Signal for Rapid Internalization of the Bovine Mannose 6-Phosphate/Insulin-Like Growth Factor II Receptor", J. Biol. Chem. 267, 11069-11077.

  20. Johnson, K.F. and Kornfeld, S. (1992) "The Cytoplasmic Tail of the Mannose 6-Phosphate/Insulin-Like Growth Factor II Receptor Has Two Signals for Lysosomal Enzyme Sorting in the Golgi", J. Cell Biol. 119, 249-257.

  21. Letourneur, F. and Klausner, R.D. (1992) "A Novel Di-Leucine Motif and a Tyrosine-Based Motif Independently Mediate Lysosomal Targeting and Endocytosis of CD3 Chains", Cell 69, 1143-1157.

  22. Chao, H.H.-J., Waheed, A., Pohlmann, R., Hile, A. and von Figura, K. (1990) "Mannose 6-Phosphate Receptor Dependent Secretion of Lysosomal Enzymes", EMBO J. 9, 3507-3513.

  23. Green, S.A., Zimmer, K-P., Griffiths, G. and Mellman, I. (1987) "Kinetics of Intracellular Transport and Sorting of Lysosomal Membrane and Plasma Membrane Proteins", J. Cell Biol. 105, 1227-1240.

  24. Williams, M.A. and Fukuda, M. (1990) "Accumulation of Membrane Glycoproteins in Lysosomes Requires a Tyrosine Residue at a Particular Position in the Cytoplasmic Tail", J. Cell Biol. 111, 955-966.

  25. Peters, C., Braun, M., Weber, B., Wendland, M., Schmidt, B., Pohlmann, R., Waheed, A. and von Figura, K. (1990) "Targeting of a Lysosomal Membrane Protein: A Tyrosine-containing Endocytosis Signal in the Cytoplasmic Tail of Lysosomal Acid Phosphatase is Necessary and Sufficient for Targeting to Lysosomes", EMBO J. 9, 3497-3506.

  26. Eberle, W., Sander, C., Klaus, W., Schmidt, B., von Figura, K. and Peters, C. (1991) "The Essential Tyrosine of the Internalization Signal in Lysosomal Acid Phosphatase Is Part of a Beta-Turn", Cell 67,1203-1209.

  27. Mathews, P.M., Martinie, J.B. and Fambrough, D.M. (1992) "The Pathway and Targeting Signal for Delivery of the Integral Membrane Glycoprotein LEP100 to Lysosomes", J. Cell Biol. 11, 1027-1040.

  28. Carlson, S.R. and Fukuda, M. (1992) "The Lysosomal Membrane Glycoprotein Lamp-1 Is Transported to Lysosomes by Two Alternate Pathways", Arch. Biochem. Biophys. 296, 630-639.

  29. Akasaki, K., Michihara, A., Mibuka, K., Fujiwara, Y. and Tsuji, H. (1995) “Biosynthetic Transport of a Major Lysosomal Membrane Glycoprotein, LAMP-1: Convergence of Biosynthetic and Endocytic Pathways Occur at Three Distinctive Points”, Exp. Cell Res. 220, 464-473.

  30. Le Borgne, R. Griffiths, G. and Hoflack, B. (1996) “Mannose 6-Phosphate Receptors and ADP-Ribosylation Factors Cooperate for High Affinity Interaction of the AP-1 Golgi Assembly Proteins with Membranes”, J. Biol. Chem. 271, 2162-2170.

  31. Mauxion, F., Le Borgne, R., Munier-Lehmann, H. and Hoflack, B. (1996) “A Casein Kinase II Phosphorylation Site in the Cytoplasmic Domain of the Cation-dependent Mannose 6-Phosphate Receptor Determines the High Affinity Interaction of AP-1 Golgi Assembly Proteins with Membranes”, J. Biol. Chem. 271, 2171-2178.

  32. Gumbiner, B. and Kelly, R.B. (1982) "Two Distinct Intracellular Pathways Transport Secretory and Membrane Glycoproteins to the Surface of Pituitary Tumor Cells", Cell 28, 51-59.

  33. Chung, K.N., Walter, P., Aponte, G.W. and Moore, H.P.H. (1989) "Molecular Sorting in the Secretory Pathway", Science, 243, 192-197.

  34. Sossin, W.S., Fisher, J.M. and Scheller (1990) "Sorting within Regulated Secretory Pathway Occurs in the Trans-Golgi Network", J. Cell Biol. 110, 1-12.

  35. Chanat, E. and Huttner, W.B. (1991) "Milieu-Induced, Selective Aggregation of Regulated Secretory Proteins in the Trans-Golgi Network", J. Cell Biol. 115, 1505-1519.

  36. Rindler, M.J., Ivanov, I.E., Plesken, H. and Sabatini, D.D. (1985) "Polarized Delivery of Viral Glycoproteins to the Apical and Basolateral Plasma Membranes of MDCK Cells Infected With Temperature-Sensitive Viruses", J. Cell Biol. 100, 136-151.

  37. Bartles, J.R., Feracci, H.M., Stieger, B. and Hubbard, A.L. (1987) "Biogenesis of the Rat Hepatocyte Plasma Membrane In Vivo: Comparison of the Pathways Taken by Apical and Basolateral Proteins Using Subcellular Fraction", J. Cell Biol. 105, 1241-1251.

  38. Gottlieb, T.A., Beaudry, G., Rizzolo, L., Colman, A., Rindler, M., Adesnik, M. and Sabatini, D.D. (1986) "Secretion of Endogenous and Exogenous Proteins from Polarized MDCK Cell Monolayers", Proc. Natl. Acad. Sci. USA 83, 2100-2104.

  39. Caplan, M.J., Stow, J.L., Newman, A.P., Madri, J., Anderson, H.C., Farquhar, M.G., Palade, G.E. and Jamieson, J.D. (1987) "Dependence on pH of Polarized Sorting of Secreted Proteins", Nature 329, 632-635.

  40. Kloppel, T.M., Brown, W.R. and Reichen, J. (1986) "Mechanism of Secretion of Proteins Into Bile: Studies in the Perfused Rat Liver", Hepatology 6, 587-594.

  41. Hughson, E.J., Cutler, D.F. and Hopkins, C.R. (1989) "Basolateral Secretion of Kappa Light Chain in the Polarized Epithelial Cell Lines, Caco-2", J. Cell Sci. 94, 327-332.

  42. Casanova, J.E., Breitfeld, P.P., Ross, S.A. and Mostov, K.E. (1990) "Phosphorylation of the Polymeric Immunoglobulin Receptor Required for Its Efficient Transcytosis", Science 248, 742-745.

  43. Hay, J.C. and Martin, T.F.J. (1992) "Resolution of Regulated Secretion into Sequential MgATP-dependent and Calcium-dependent Stages Mediated by Distinct Cytosolic Proteins", J. Cell Biol. 119, 139-151.

  44. Regnier-Vigouroux, A., Tooze, S.A. and Huttner, W.B. (1991) "Newly Synthesized Synaptophysin Is Transported to Synaptic-like Microvesicles via Constitutive Secretory Vesicles and the Plasma Membrane", EMBO J. 10, 3589-3601.

  45. Bennett, M.K., Calakos, N., Kreiner, T. and Scheller, R.H. (1992) "Synaptic Vesicle Membrane Proteins Interact to Form a Multimeric Complex", J. Cell Biol. 116, 761-775.

  46. Grote, E. et al. (1995) “A Targeting Signal in VAMP Regulates Transport to Synaptic Vesicles”, Cell 81, 581-589.