Principal Investigator:
John Castellot, Ph.D.
Professor and Director of the CMDB Graduate Program
Department of Anatomy and Cellular Biology

Department of Anatomy & Cellular Biology
Tufts University 
School of Medicine
136 Harrison Avenue
Boston, Massachusetts 02111

Office Phone:  
(617)636-0303
Lab Phone: 
(617)636-
FAX: 
(617)636-6536

EMail Address:
john.castellot@tufts.edu


Program in Cellular and Molecular Biology

Sackler School

Medical School

Fig. 1. Anatomy of the artery wall. The media consists of SMC embedded in extracellular matrix. When the endothelial cells in the intima are damaged, as often happens during vascular surgery, the medial SMC respond by migrating through the internal elastic lamina (IEL) into the intima and proliferating, as seen in Fig. 2. In larger arteries such as the aorta or carotid, several additional elastic laminae are present in the media.