Principal Investigator:
John Castellot, Ph.D.
Professor and Director of the CMDB Graduate Program
Department of Anatomy and Cellular Biology

Department of Anatomy & Cellular Biology
Tufts University 
School of Medicine
136 Harrison Avenue
Boston, Massachusetts 02111

Office Phone:  
(617)636-0303
Lab Phone: 
(617)636-
FAX: 
(617)636-6536

EMail Address:
john.castellot@tufts.edu


Program in Cellular and Molecular Biology

Sackler School

Medical School

Fig. 7 CCN5 expression in uterine fibroids. Matched pairs of human fibroid (leiomyoma) tissue and the adjacent normal myometrium from the same uterus were examined for CCN5 levels using Western blot analysis. The phase of the menstrual cycle—proliferating, secretory, or menstrual—was also determined. The actively proliferating fibroid SMC samples express very low levels of CCN5, whereas the normal myometrium samples containing non-proliferating SMC express much higher levels.