Principal Investigator:
Athar Chishti, Ph.D.
Associate Professor,
University
of Melbourne, Australia, 1984
Chief, Section of Hematology and Oncology Research
St. Elizabeth's Medical Center,
736 Cambridge, Street Boston, MA 02135
Department of Anatomy & Cellular Biology
Tufts University
School of Medicine
136 Harrison Avenue
Boston, Massachusetts 02111
Phone:
(617)
789-3118
FAX:
(617)
789-3111
EMail
Address:
Athar.Chishti@tufts.edu
Program
in Cellular and Molecular Biology
Sackler School
Medical
School
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Selected Publications Morais-Cabral, J.H., Petrosa, C., Poy, F., Marfatia, S.M., Chishti, A.H., Liddington, R.C. (1996). Crystal Structure of a PDZ domain from the human homologue of discs-large protein. Nature 382:649-652. Marfatia, S.M., Morais-Cabral, J.H., Lin, L., Hough, C., Bryant, P.J., Stolz, L., Chishti, A.H. (1996). Modular organization of the PDZ domains in the human discs large protein suggests a mechanism for coupling PDZ domain binding proteins to ATP and the membrane cytoskeleton. J. Cell Biol. 135:753-766. Southgate, C.D., Chishti, A.H., Mitchell, B., Yi, S.J. and Palek, J. (1996). Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anemia despite a normal membrane skeleton. Nature Genetics 14: 227-230. Songyang, Z., Fanning, A.S., Fu, C., Xu, J., Marfatia, S.M., Chishti, A.H., Crompton, A., Chan, A.C., Anderson, J.M. and Cantley, L.C. (1997). Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275:73-77. Hanada, T., Lin, L., Chandy, K.G., Oh, S.S. and Chishti, A.H. (1997). Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes. J. Biol. Chem. 272:26899-26904. Chishti, A.H., et al. (1998). The FERM domain: A unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends in Biochemical Sciences (TiBS) 23:281-282. Marfatia, S., Byron, O., Campbell, G., Liu, S-C. and Chishti, A.H. (2000). Human Homologue of the Drosophila Discs Large Tumor Suppressor Protein Forms an Oligomer in Solution. Identification of the self-association Site. J. Biol. Chem. 275, 13759-13770. Oh, S.S., Voight, S., Fisher, D., Yi, S.J., LeRoy, P.J., Liu, S-C. and Chishti, A.H. (2000). Plasmodium falciparum erythrocyte membrane protein 1 is anchored to the actin-spectrin junction and knob-associated histidine-rich protein in the erythrocyte skeleton. Molecular and Biochemical Parasitology 108:237-247. Hanada, T., Lin, L., Tibaldi, E.V., Reinherz, E.L., and Chishti, A.H. (2000). GAKIN: A Novel Kinesin-like Protein Associates with the Human Homologue of the Drosophila Discs Large Tumor Suppressor in T Lymphocytes. J. Biol. Chem. 275:28774-28784. Azam, M., Andrabi, S.S., Sahr, K.E., Kamath, L., Kuliopulos, A., and Chishti, A.H. (2001). Disruption of the mouse m-calpain gene reveals an essential role in platelet function. Molecular and Cell Biology 21:2213-2220. Lutchman, M., Kim, A.C., Cheng, L., Whitehead, I.P., Oh, S.S., Hanspal, M., Boukharov, A.A., Hanada, T., Chishti. A.H. (2002). Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways. European Journal of Biochemistry 269, 638-649. Hanspal,
M., Dua, M., Takakuwa, Y., Chishti, A.H. and Mizuno, A. (2002).
Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte
membrane skeletal proteins at late stages of parasite development.
BLOOD Hanspal, M., Goel, V., Oh, S.S., Chishti, A.H. (2002). Erythrocyte calpain is dispensable for malaria parasite invasion and growth. Molecular Biochemical Parasitology 122:227-229. Khanna, R., Chang, S.C., Andrabi, S., Azam, M., Kim, A., Rivera, A., Brugnara, C., Low, P.S., Liu, S-C., Chishti, A.H. (2002). Headpiece domain of dematin is required for the stability of the erythrocyte membrane. Proc. Natl. Acad. Sci. (USA) (in press). |
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