DAMASSA LABORATORY

Androgens are steroid hormones that play a critical role in the normal development and maintenance of "male" sexual characteristics. During fetal life, androgens secreted by the testes induce the formation of many components of the male reproductive system, including internal structures such as the prostate gland. In adults, normal prostate function, as well as the development of cancer in this gland, are androgen dependent. The major focus of our research is to understand the molecular mechanisms involved in the action of androgens in the regulation of both normal and abnormal development of the male reproductive system. A key element in the action of androgens is believed to be the binding of these steroids to nuclear androgen receptors. However, another androgen-binding protein, sex hormone binding globulin (SHBG), is produced by many steroid-sensitive cells.

Studies to examine the role of SHBG in androgen action are being conducted using a novel rodent model. A specific SHBG has been identified in the plasma of the Djungarian hamster. As in humans, this species shows increased SHBG synthesis immediately after birth. Using specific antisera and cDNA probes, we are examining the tissue specific regulation and actions of SHBG during development. Ultimately, our work will help to define the interactions between androgens and SHBG in the development and function of androgen-sensitive tissues.