Lab Home Coworkers and Collaborators Selected Publications Research Expertise



Principal Investigator:
Thomas Ducibella, Ph.D
Professor, Ph.D., Princeton, 1973

OB/GYN, TUSM, Boston Campus

Tufts-New England Medical Center
Box 36, OB/GYN
750 Washington Street
Boston, MA 02111
617 636-5000

Department of Anatomy & Cellular Biology
Tufts University 
School of Medicine
136 Harrison Avenue
Boston, Massachusetts 02111

Office Phone:  
(617)636-2627
Lab Phone: 
(617)636-2628
FAX: 
(617)636-5087


EMail Address:
tducibella@tufts-nemc.org

Program in Cellular and Molecular Biology

Sackler School

Medical School

 

 

Selected Publications
 

Abbott, A., Fissore, R., and Ducibella, T. Identification of a translocation deficiency in cortical granule secretion in preovulatory mouse oocytes. Biology of Reproduction 65, 1640-47, 2001.

Abbott, A., and Ducibella, T. Calcium and the Control of Mammalian Cortical Granule Exocytosis. Frontiers In Bioscience, 6, d792-806, 2001.

Smyth, J.T., Abbott, A., Lee, B., Sienaert, I., Kasri, N., De Smedt, H., Ducibella, T., Missiaen, L., Parys, J.B, and Fissore, R. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/Calmodulin-dependent protein kinase II antagonism. J. Biological Chemistry, 277, 35061-35070, 2002.

Ducibella, T., Huneau, D., Angelichio, E., Schultz, R. M., Guessova, G., Xu, Z., Kopf, G. S., Fissore. R., Madoux, S., and Ozil, J.-P. Egg-to-Embryo transition is driven by differential responses to Ca2+ oscillation number. Developmental Biology, 250, 280-291, 2002.

Markoulaki, S., Matson, S., Abbott, A.L., and Ducibella, T. Oscillatory CaMKII activity in mouse egg activation. Developmental Biology 258, 464-474, 2003.

Markoulaki, S., Matson, S., and Ducibella, T. Fertilization stimulates long-lasting oscillations of CaMKII activity in mouse eggs. Developmental Biology, 272, 15-25, 2004.

Ozil, J.-P., Markoulaki, S., Szabolcs, T., Matson, S., Banrezes, B., Knott, J., Schultz, R. M., Huneau, D., and Ducibella, T. Egg Activation events are regulated by the duration of a sustained [Ca2+](cyt) signal in the mouse. Developmental Biology 282, 39-54, 2005.

Florman, H. and Ducibella, T. Mammalian Fertilization. In: The Physiology of Reproduction, 3rd Ed., Elsevier Press, in press.

Ducibella, T., Schultz, R.M., and Ozil, J.-P. Role of calcium signals in early development. Seminars in Cell and Developmental Biology, in press.

Matson, S., Markoulaki, S., and Ducibella, T. Antagonists of myosin light chain kinase and of myosin II inhibit specific events of egg activation in fertilized mouse eggs. Biology of Reproduction, in press.


Program in Cell, Molecular, and Developmental Biology
136 Harrison Avenue, 5th Floor
Boston, MA 02111 617-636-6685

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page last modified 10/31/05