| Selected
Publications
Mendez,
A., Lem, J., Simon. M., and Chen, J. Light-dependent translocation
of arrestin in the absence of rhodopsin phosphorylation and transducin
signaling. (2003) J. Neurosci. 23:3124-3129.
Hattar, S., Lucas, R.J.,
Mrosovsky, N., Thompson, S., Douglas, R.H., Hankins, M.W., Lem,
J., Biel, M., Hofmann, F., Foster, R.G. and Yau, K.-W. (2003) Melanopsin
and rod-cone photoreceptive systems account for all major accessory
visual functions in mice. Nature 424:76-81.
Martemyanov, K.A., Lishko, P.V., Calero, N., Keresztes, G.T., Sokolov,
M., Strissel, K.J., Leskov, I.B., Hopp, JA., Kolesnikov, A.V., Chen,
C.-K., Lem, J., Heller, S., Burns, M.E. and Arshavsky, V.Y. (2003)
The DEP domain determines subcellular targeting of the GTPase activating
protein RGS9 in vivo. J. Neurosci. (In Press).
Woodruff, M.L., Wang,
Z., Chung, H.Y., Redmond, T.M., Fain, G.L., and Lem, J. (2003) Spontaneous
activity of opsin apoprotein is a cause of Leber congenital amaurosis.
Nat. Genet. 35:158-164.
Brill, E., Patnala, S.,
Lem, J. and Obin, M. (2003) Bright Light Induces Retinal Degeneration
by a Transducin-Independent Mechanism. Advances in Experimental
Medicine and Biology; Retinal Degeneration: Mechanisms and Experimental
Therapy. M.M. LaVail, J.G. Hollyfield, and R.E. Anderson, eds. Kluwer
Academic/Plenum Publishers, New York, pp. 213-219.
Makino, C., Wen, X.-H.,
and Lem, J. (2003) Piecing together the timetable for visual transduction
with transgenic animals. Current Opinion in Neurobiology 13:404-412.
Hao, W., Wenzel, A.,
Obin, M.S., Chen, C-K., Brill, E., Krasnoperova, N.V., Eversole-Cire,
P., Kleyner, Y., Taylor, A., Simon, M.I., Grimm, C., Remé,
C.E. and Lem, J. Evidence for Two Apoptotic Pathways in Light-Induced
Retinal Degenerations. (2002) Nature Genetics: 32: 254-260.
Woodruff ML, Sampath
AP, Matthews HR, Krasnoperova NV, Lem JL, Fain GL. Measurement of
cytoplasmic calcium concentration in the rods of wild-type and transducin
knock-out mice. J of Physiology 542.3:843-854, 2002.
Lyubarsky AL, Lem J,
Chen J, Falsini B, Iannaccone A, Pugh Jr EN. Functionally rodless
mice: transgenic models for the investigation of cone function in
retinal disease and therapy. Vision Research 42:401-415, 2002.
Calvert PD, Govardovskii
VI, Krasnoperova N, Anderson RE, Lem J, Makino CL. Effect of rhodopsin
membrane density on the speed of rod phototransduction. Nature 411:90-94,
2001.
Calvert PD, Krasnoperova NV, Lyubarsky AL, Isayama T, Nicolo M,
Kosaras B, Wong G, Gannon KS, Margolskee RF, Sidman RL, Pugh EN
Jr, Makino CL, Lem J. Phototransduction in transgenic mice after
targeted deletion of the rod transducin a-subunit. Proc Natl Acad
Sci USA 97:13913-13918, 2000.
|
