Lab Home Coworkers and Collaborators Selected Publications Research Expertise



Principal Investigator:
Noorjahan Panjwani, PhD

Director of Research,
Department of Ophthalmology,
New England Eye Center

Professor of Ophthalmology
and Biochemistry,
Tufts University School of Medicine


Program in Cell, Molecular and Developmental Biology

Department of Anatomy & Cellular Biology
Tufts University 
School of Medicine
136 Harrison Avenue
Boston, Massachusetts 02111


Office Phone:  
(617)636-6776
Lab Phone: 
(617)636-3628
FAX: 
(617)636-6536

EMail Address: Noorjahan.Panjwani@tufts.edu

Sackler School

Medical School

 

 

Representative Publications

Garate M, Alizadeh H, Neelam S, Niederkorn J, and Panjwani N: Oral immunization with Acanthamoeba mannose-binding protein provides protection against amoebic keratitis. Infect Immun (in press).

Cao Z, Saravanan C, Goldstein MH, Wu HK, Pasricha G, Sharma S, and Panjwani N: Human tears inhibit Acanthamoeba-induced cytopathic effect. Arch Ophthalmol, in revision 2006 (submitted)


Diskin, S, Kumar, J, Cao, Z, Schuman, JS, Gilmartin, T, Head, SR, Panjwani N. Detection of Differentially Expressed Glycogenes in Trabecular Meshwork of Primary Open-Angle Glaucoma Eyes. Invest Ophthalmol Vis Sci. 47(4):1491-1499, 2006.

Garate, M, Marchant, J,Cubillos, I,Cao, Z, Khan, NA, Panjwani N. In vitro Pathogenicity of Acanthamoeba is Associated with the Expression of the Mannose-Binding Protein. Invest Ophthalmol Vis Sci. 47(3):1056-62, 2006.

Garate M, Cubillos I, Marchant J, Panjwani N. Biochemical characterization and functional studies of Acanthamoeba mannose-binding protein. Infect Immun. 2005 Sep;73(9):5775-81.

Garate M, Cao Z, Bateman E, and Panjwani N: Cloning and characterization of a novel mannose-binding protein of Acanthamoeba. J Biol Chem. 9;279(28):29849-56, 2004.

Cao Z, Said N, Wu HK, Kuwabara I, Lui F-T, and Panjwani N: Galectin-7. a potential mediator of corneal epithelial cell migration. Arch Opthalmol 121:82-86, 2003

Cao Z, Said N, Amin S, Wu HK, Bruce A, Garate M, Hsu, DK, Kuwabara I, Lui FT, and Panjwani N: Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds. J Biol Chem 277:42299-42305, 2002

Cao, Zhiyi, Helen K. Wu, Amenda Bruce, Kurt Wollenberg, Fu-Tong Liu, and Panjwani N. Detection of differentially expressed genes in healing mouse corneas using cDNA microarrays. Invest Opthalmol Vis Sci 43:2897-2904, 2002 (Microarray Data Files)

Cao Z, Zhao Z, Alroy JL, Stanley P, and Panjwani N: A Potential Role for the Lewisx Glycan Determinant in Corneal Epithelial Cell Adhesion and Differentiation. J Biol Chem 276:21714-21723, 2001

Khan NA, Harroll EL, Panjwani N, Cao ZY, and Paget TA: Proteases as markers for differentiation of pathogenic and nonpathogenic species of Acanthamoeba. J Clin Microbiol 38:2858-2861, 2000.

Terraciano AJ, Wang N, Schuman JS, Haffner G, Panjwani N, Zhao Z, and Yang Z: Sialyl Lewis X, Lewis X, and N-acetyllactosamine expression on normal and glaucomatous eyes. Curr Eye Res 18:73-78, 1999.

Cao Z, Jefferson DM, and Panjwani N: Role of carbohydrate-mediated adherence in cytopathogenic mechanisms of Acanthamoeba. J Biol Chem 273:15838-5845, 1998.

Paliakkara-Lona J, Cao Z, and Panjwani N: Binding of Acanthamoeba to mannose-glycoproteins of corneal epithelium: effect of injury. Curr Eye Res 17:770-776, 1998

Panjwani N, Zhao Z., Baum J, Hazlett, LD, and Yang Z: Acanthamoeba bind to rabbit corneal epithelium in vitro. Invest Ophthalmol Vis Sci 38:1858-1864, 1997.

Yang Z, Cao Z and Panjwani N: Pathogenesis of Acanthamoeba keratitis: carbohydrate-mediated host-parasite interactions. Infect Immun 65:439 -445, 1997.

Panjwani N, Zhao Z, Raizman M, and Jungalwala F: Pathogenesis of corneal infection: binding of Pseudomonas aeruginosa to specific phospholipids. Infect Immun 64:1819-1825, 1996.

Yang Z, Zhao Z, and Panjwani N: Gangliosides of migrating and nonmigrating corneal epithelium in organ and cell culture. Invest Ophthalmol Vis Sci 37:501-510, 1996.

Mohan R, Lee B, and Panjwani N: Molecular cloning of the E-cadherin cDNAs from rabbit corneal epithelium. Curr Eye Res 14:1135-1145, 1995.

Panjwani N, Zhao Z, Ahmad S, Yang Z, Jungalwala F, and Baum J. Neolactoglycosphingolipids, potential mediators of corneal epithelial cell migration. J Biol Chem 270:14015-14203, 1995.

Book Chapters

Panjwani N: Cornea and Sclera In Harding JJ (ed): Biochemistry of the Eye. Chapman and Hall Ltd, London, pp 16-51, 1997

Panjwani N and Mohan R: Sclera. In Krachmer J, Mannis N, and Holland E (eds): Cornea. Mosby Year Book, St. Louis, pp 29-40, 1997


Program in Cell, Molecular, and Developmental Biology
136 Harrison Avenue, 5th Floor
Boston, MA 02111 617-636-6685

Questions and comments to: Web Development

page last modified 9/27/06