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Stephen
C. Bunnell, Ph.D. |
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Assistant Professor of Pathology
Immunology
stephen.bunnell@tufts.edu
We are interested in the signaling complexes
that control T cell differentiation and activation. Using advanced
imaging techniques we examine the assembly and localization
of these complexes in living T cells. The composition of these
structures varies dynamically in a fashion that reflects the
physiological constraints on T cell activation. We have shown
that these structures cannot persist in the absence of any of
several critical proteins. These proteins are therefore likely
to form a cooperatively assembled core complex upon which complete
signaling complexes are built. Finally, we have found that these
complexes change in localization over time. We are currently
defining the components of the core complex and are testing
how changes in localization affect the generation of signals
uniquely required for T cell activation.
Visit
the Bunnell research web site |
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