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John J. Castellot, Jr., Ph.D. |
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Professor of Anatomy and Cellular Biology
Director of the Cell, Molecular, and Developmental Biology Program
Cell, Pharmacology
john.castellot@tufts.edu
Aberrant proliferation of smooth muscle cells plays a key role in disease processes as diverse as arteriosclerosis, restenosis following vascular surgery (the cause of failure in hundreds of thousands of procedures each year in the U.S.), uterine fibroids, and several congenital defects. We have recently cloned a novel growth arrest-specific (gas) gene that inhibits smooth muscle cell proliferation, and are exploring its mechanism of action and potential use in gene or protein therapy for restenosis and uterine fibroids. We are also examining the role of this gene in formation of the vasculature in the developing embryonic limb.
Visit the Castellot, Jr. research web site |
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