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Jinkun
(Jake) Chen, D.D.S., Ph.D. |
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Professor
of General Medicine, School of Dental Medicine
Cell
JK.Chen@tufts.edu
Bone sialoprotein (BSP) is a major non-collagenous protein in
bone and other mineralized tissues. Our lab has demonstrated
that that BSP is expressed during de novo bone formation and
in initial stage of mineralization. Using transgenic mouse model
we were the first in reporting the expression of rat BSP promoter
in a tissue specific and developmentally regulated fashion.
The transcriptional factor Cbfa1 is a "master gene"
in osteogenenis. In Cbfa1 deficient mice there was no bone formation.
We are currently investigating the regulation of Cbfa1 on BSP
gene expression.
Visit the Chen research web site |
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