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Thomas Ducibella, Ph.D. |
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Professor of Obstetrics and Gynecology
Cell
tom.ducibella@tufts.edu
Although fertilization is the most fundamental event of early development, biologists are only beginning to unravel the mechanisms responsible for signaling the completion of meiosis, cell division (cleavage), synthesis of embryonic proteins, and prevention of multiple sperm penetration by regulated secretion. Our research is aimed at discovering the normal pathways activating these critical events, including when the egg develops the biochemical machinery driving these pathways, and the molecular causes of human in vitro fertilization failure. Studies utilize sensitive biochemical and fluorescence assays as well as quantitative computerized image analysis of cell organelles, cell cycle kinases, and secretory or extracellular matrix proteins.
Visit the Ducibella research web site |
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