Recent advances in the engineering of three-dimensional tissues have opened new opportunities to study human disease processes in stratified squamous epithelium. Our laboratory uses these tissue models to understand the role of cell-cell and cell-matrix interactions during early cancer development. We are particularly interested in understanding the molecular changes that accompany the onset of metastasis. The engineered models of human skin we are using also provide powerful new tools to study other disease processes in these tissues as they occur in humans.

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