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David J. Greenblatt, M.D. |
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Louis Lasagna Professor of Pharmacology
and Experimental Therapeutics
Pharmacology, Biochemistry
dj.greenblatt@tufts.edu
Events between entry of a drug into the body and its ultimate interaction with a specific receptor site are the focus of this laboratory's research, including: drug absorption from the gastrointestinal tract and other extravascular sites; regulation and prediction of drug diffusion and/or transport to extravascular tissues; processes of drug metabolism and biotransformation by the cytochromes P450 enzymes and by glucuronyl transferases; presystemic extraction by the liver and gastrointestinal tract mucosa; in vitro models of drug metabolism; drug interactions; ligand binding and altered chloride channel permeability of the GABA-benzodiazepine receptor complex; pharmacodynamic consequences of benzodiazepine agonist ligand binding; benzodiazepine ligand pharmacokinetics and receptor sensitivity; altered receptor function as a consequence of chronic drug exposure.
Visit the Greenblatt research web site |
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