Our research interests are focused in molecular endocrinology with an emphasis on G protein-coupled receptors (GPCRs). Investigations are aimed at defining structure-function relationships of GPCRs including the identification of ligand binding determinants and the mechanisms of signal transduction (ligand and/or mutation induced). Based on this expertise, the laboratory has developed molecular tools to expedite GPCR drug discovery.  In addition, our research directions combine in vitro approaches with in vivo models (e.g. knockout mice, transgenic Drosophila) to define the physiologic functions mediated by GPCRs. The cholecystokinin/gastrin, dopamine, serotonin, GABA-B, and opioid receptor families are currently under study.

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