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Karina F. Meiri, Ph.D. |
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Professor
of Anatomy and Cellular Biology
Cell, Neuroscience, Pharmacology
karina.meiri@tufts.edu
All stages in the acquisition of a neuronal phenotype require both structural and functional polarization of the neuron. This is achieved in part by the neuron's ability to regulate the action cytoskeleton in response to extracellular signals. We have taken a cellular and molecular approach and are focused on understanding how membrane microdomains in developing neurons form spatially segregated signaling scaffolds that enable a directional response to extracellular cues. A key finding is that the same molecular machinery is involved at each stage of the neuronal life cycle, to initiate cell cycle control, polarization, and to mediate axon pathfinding.
Visit the Meiri research web site |
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