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Michael E. Mendelsohn, M.D. |
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Professor of Medicine
Biochemistry, Physiology,
Cell
MMendelsohn@Tufts-nemc.org
Our laboratory, part of the Molecular Cardiology Research Institute I direct, studies signal transduction pathways in vascular cells. We focus on the molecular signaling mechanisms and resulting protective effects of two endogenous, vasoprotective molecules: estrogen and nitric oxide and its second messenger cyclic GMP. The institute has a $9.8 million NIH award to explore the role of estrogen receptors and the genes they regulate in ischemic cardiovascular diseases. Other projects include studies of molecular mechanisms of cGMP-dependent protein kinase action; cloning and characterization of cGMP-regulated ion channels from human vascular cells; studies of the molecular signal transduction pathways involved in the rapid effects of estrogen on vascular cells; and identification of novel estrogen-regulated genes in vascular cells.
Visit the Mendelsohn research web site |
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