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Peter H. Brodeur, Ph.D. |
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Associate Professor of Pathology
Genetics, Immunology
peter.brodeur@tufts.edu
Humoral immunity consists of pathogen-specific proteins called antibodies (immunoglobulins). These exquisitely specific proteins are the product of V(D)J recombination, a process that cuts and splices DNA to create millions of distinct antibodies, each capable of recognizing a particular microbe. To understand this fundamental process, we are studying the regulation of the mouse Igh locus (immunoglobulin heavy chain) during B lymphocyte development. We are employing a combination of gene mapping, transgenic, and cell culture models to elucidate the signaling pathways and transcriptional regulation required to orchestrate this unique genetic mechanism.
Visit the Brodeur research web site |
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