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Michael Rosenblatt, M.D.
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Dean of the School of Medicine
and Professor of Physiology
Cellular annd Molecular Physiology
Genetics
michael.rosenblatt@tufts.edu
My laboratory engages in research in
two areas: 1) the structural biology of hormone--receptor interactions
in the parathyroid hormone field; 2) understanding the mechanisms
of cancer metastasis to bone. In this first project, we are
using photoaffinity cross-linking to map the bimolecular interface
between parathyroid hormone and its cognate receptor. Together
with nmr and computer-assisted molecular modeling, we are building
an experimentally-derived model of the hormone--receptor complex.
In the second project, we have created an “all-human”
animal model of breast cancer metastasis to bone. We seek to
identify the genes associated with and mechanisms responsible
for cancer “homing” to the skeleton, termed osteotropism.
Visit the Rosenblatt research web site |
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