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James E. Schwob, M.D., Ph.D. |
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Professor of Anatomy and Cellular
Biology
Cell, Neuroscience
jim.schwob@tufts.edu
The mechanisms regulating neural development are beginning to relinquish their secrets through molecular biological investigations of simple model systems. We use the peripheral olfactory (smell) system to model fundamental developmental processes, including the controlled generation of neurons and directed axon growth. We have chosen this model because neurogenesis, and targeted reinnervation of the CNS remain robust throughout life, offering many experimental advantages. Furthermore, the olfactory system offers exquisite examples of both processes, since the roughly 1000 different types of olfactory neurons that are generated (each type defined by the expression of one of the large family of odorant receptor genes) each innervate a distinct target in the brain.
Visit the Schwob research web site |
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