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Barbara R. Talamo, Ph.D. |
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Professor of Neuroscience
Neuroscience, Physiology
barbara.talamo@tufts.edu
Olfactory nerve cell responses to odorants are investigated to understand how information is processed and how an artificial nose might be improved to mimic the highly sensitive and discriminating biological olfactory system. A model olfactory cell line provides a new tool for functional expression of odorant receptors and signaling proteins in the biochemical response cascade. Nerve signals alter postsynaptic receptivity by changing expression and function of signaling molecules in postsynaptic cells. Pharmacological, molecular, biochemical, and imaging studies in my laboratory show that P2 receptors for extracellular ATP are dramatically regulated by changes in parasympathetic innervation of secretory cells, suggesting that extracellular ATP plays a functional role in regulating nerve signaling.
Visit the Talamo research web site |
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