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Barry A. Trimmer, Ph.D. |
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Professor of Biology, School
fo Arts and Sciences
Neuroscience, Pharmacology
barry.trimmer@tufts.edu
We focus on understanding how cell signaling contributes to the functions of the central nervous system (CNS), in particular the mechanisms that mediate information processing and allow appropriate response to sensory input. We use the hawkmoth caterpillar (Manduca sexta), which exhibits complex behavior generated by a (relatively) simple CNS. Most recently, we are studying the functional roles of two transmitters, acetylcholine (ACh) and nitric oxide (NO). Using electrophysiology, biochemistry, and molecular biology we have established that two different families of ACh receptors transduce sensory signals, subsequently encoded by neuron-specific electrical and biochemical changes. In contrast, the neurotransmitter role of NO remains enigmatic.
Visit the Trimmer research web site |
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