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Jin-Hwan Han,
B.S. Biotechnology, Our lab is interested in molecular and cellular mechanism of pathogenesis of systemic lupus erythematosus (SLE). This systemic autoimmune disease is characterized by the production of pathogenic anti-nucleic acid/-nucleosome antibodies which cause glomerulonephritis when deposited in the kidneys. The (SWR x NZB)F1 (SNF1) mouse is an excellent in vivo model of human SLE. Pathogenic autoantibodies are highly somatically mutated and they are predominantly IgG2a or IgG2b, suggesting that activation-induced cytidine deaminase (AID) may contribute to their formation.. My project is to investigate the potential role of AID in formation of self- reactive antibody repertoire in our SLE mouse model |
