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Annie Moseman,
B.A., Biology, The innate immune system detects bacterial nucleic acids via CpG motifs to promote both innate inflammatory responses and antigen-specific adaptive responses. I am studying CpG hypo-responsiveness in a genetically diverse wild-derived MOLF/Ei mice, a strain in macrophages but not plasmacytic dendritic cells are partially responsive to CpG motifs. I am studying the signaling pathways that are involved in this phenotype. I am also working to identify the genes that control this response. |
