Selected Publications

Conner, J. R., Smirnova, I. I., Poltorak, A.2009. A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice. J. Exp. Med. 206:1615-1631.
[Abstract]

Losick, V. P., Stephan, K., Smirnova, I. I., Isberg, R. R., and Poltorak, A.2009. A hemidominant Naip5 allele in MOLF/Ei-derived macrophages restricts L. pneumophila intracellular growth. Inf. Inmmun. 77, 196-204.
[Abstract]

Conner, J. R., Smirnova, I. I., and Poltorak, A. 2008. Forward genetic analysis of toll-like receptor responses in wild-derived mice reveals a novel anti-inflammatory role for IRAK1BP1. J. Exp. Med.205: 305-314.
[Abstract] .

Stephan, K., Smirnova, I., Jacque, B., and Poltorak, A. 2007. Genetic analyses of the innate immune responses in wild-derived strains of mice. Eur. J. Immunol. 37: 212-223.
[Abstract]

Jacque, B., Stephan, K., Smirnova, I., Kim, B., Gilling, D., and Poltorak, A. 2006. Mice expressing high levels of soluble CD14 retain LPS in the circulation and are resistant to LPS-induced lethality. Eur. J. Immunol. 36: 1-10.
[Abstract]

Ehl, S., Bischoff, R., Ostler, T., Vallbracht, S., Schulte-Monting, J., Poltorak, A., Freudenberg, M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur. J. Immunol. 34: 1146-1153.
[Abstract]

Coutinho, A. and Poltorak, A. 2003. Innate immunity: from lymphocyte mitogens to Toll-like receptors and back, Curr. Opin.Immunol., 15: 599-602.
[Abstract]

Kalis, C. Kanzler, B., Lembo, A., Poltorak, A., Galanos, C., Freudenberg, M A. 2003.Toll-like receptor 4 expression levels determine the degree of LPS- susceptibility in mice. Eur.J.Immunol., 33: 798-805.
[Abstract]

Poltorak, A., Merlin, T., Nielsen, P. J., Sandra, O., Smirnova, I., Schupp, I., Boehm, T., Galanos, C., and Freudenberg, M. A. 2001. A point mutation in the IL-12R ⓶ gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice. J. Immunol. 167: 2106-2111.
[Abstract]

Beutler, B., and Poltorak, A. 2001. Sepsis and the evolution of the innate immune response. Crit. Care Med. 29:S2-S7.
[Abstract]