Immunology Home

Faculty

Program Overview

Courses

Location

Admissions

Current Students

Student Publications

Seminars

Seminar Schedule

Student Workshop

Workshop Schedule

Journal Club

Retreat

Student Activities

Alumni

Program Staff

Sackler School

Tufts University

 


Recent Publications by Our Students

2008

Conner, J. R., Smirnova, I. I., and Poltorak, A. 2008. Forward genetic analysis of toll-like receptor responses in wild-derived mice reveals a novel anti-inflammatory role for IRAK1BP1. J. Exp. Med. 205: 305-314.
[
Abstract]

Hadinoto, V., Shapiro, M., Greenough, T. C., Sullivan, J. L., Luzuriaga, K., and Thorley-Lawson, D. A. 2008. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood 111: 1420-1427.
[
Abstract]

2007

Ashworth, T. and Roy, A. L. 2007. Cutting Edge: TFII-I controls B cell proliferation via regulating NF-κB. J. Immunol. 178: 2631-2635.
[Abstract]

Budde, P. P., Davis, B. M., Yuan, J., and Waldor, M. K. 2007. Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. J. Bacteriol. 198: 491-500.
[Abstract]

Castiglione, F., Duca, K., Jarrah, A., Laubenbacher, R., Hochberg, D., and Thorley-Lawson, D. 2007. Simulating Epstein-Barr virus infection with C-ImmSim. Bioinformatics 23: 1371-1377.
[Abstract]

Chen, G., Tai, A. K., Lin, M., Chang, F., Terhorst, C., and Huber, B. T. 2007. Increased proliferation of CD8(+) T cells in SAP-deficient mice is associated with impaired activation-induced cell death. Eur. J. Immunol. 37: 663-674.
[Abstract]

de Melo-Jorge, M. and PereiraPerrin, M. 2007. The Chagas' Disease parasite Trypanosoma cruzi exploits nerve growth factor receptor TrkA to infect mammalian hosts. Cell Host & Microbe 1: 251-261.
[Abstract]

Duca, K. A., Shiprio, M., Delgado-Eckert, E., Hadinoto, V., Jarrah, A. S., Laubenbacher, R., Lee, K., Luzuriaga, K., Polys, N. F., and Thorley-Lawson, D. 2007. A vitrual look at Epstein-Barr virus infection: Biological interpretation. Plos Pathog. 3: 1388-1400.
[Abstract]

Ghosh, S. and Huber, B. T. 2007. Clonal diversification in OspA-specific antibodies from peripheral circulation of a chronic Lyme arthritis patient. J. Immunol. Methods. 321: 121-134.
[Abstract]

Hadinoto, V., Shapiro, M., Greenough, T. C., Sullivan, J. L., Luzuriago, K., and Thorley-Lawson, D. 2007. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood Epub ahead of print.
[Abstract]

Han, J. H., Akira, S., Calame, K., Beutler, B., Selsing, E., and Imanishi-Kari, T. 2007. Class switch recombination and somatic hypermutation in early mouse B Cells are mediated by B Cell and toll-like receptors. Immunity 27: 64-75.
[Abstract]

Huang, F. T., Yu, K., Balter, B. B., Selsing, E., Oruc, Z., Khamlichi, A. A., Hsieh, C. L., and Lieber, M. R. 2007. Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Sμ class switch region. Mol. Cell. Biol. 27: 5921-5932.
[Abstract]

Iliopoulou, B. P., Alroy, J., and Huber, B. T. 2007. CD28 Deficiency exacerbates joint inflammation upon Borrelia burgdorferi infection, resulting in the development of chronic Lyme arthritis. J. Immunol. 179: 8076-8082.
[Abstract]

Mathur, J., Davis, B. M, and Waldor, M. K. 2007. Antimicrobial peptides activate the Vibrio cholerae sigmaE regulon through an OmpU-dependent signalling pathway. Mol Microbiol. 63: 848-58.
[Abstract]

Pegtel, D. M., Subramanian, A., Merritt, D., Tsai, C. H., Sheen, T. S., Golub T. R., and Thorley-Lawson, D. A. 2007. IFN-α-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas. Cancer Res. 67: 474-481.
[Abstract]

Shainheit, M. G., Saraceno, R., Bazzone, L. E., Rutitzky, L. I., and Stadecker, M. J. 2007. Disruption of interleukin-27 signaling results in impaired gamma interferon production but does not significantly affect immunopathology in murine schistosome infection. Infect. Immun. 75: 3167-3177.
[Abstract]

Shin, S. O., Behera, A. K., Bronson, R. T., and Hu, L. T. 2007. Role of novel protein kinase C isoforms in Lyme arthritis. Cell. Microbiol. 9: 1987-1996.
[Abstract]

Stephan, K., Smirnova, I., Jacque, B., and Poltorak, A. 2007. Genetic analyses of the innate immune responses in wild-derived strains of mice. Eur. J. Immunol. 37: 212-223.
[Abstract]

Souza, T. A., Stollar, B. D., Sullivan, J. L., Luzuriaga, K., and Thorley-Lawson, D.A. 2007. Influence of EBV on the peripheral blood memory B cell compartment. J. Immunol. 179: 3153-3160.
[Abstract]

Sun, C. C. and Thorley-Lawson, D., 2007. Plasma cell-specific transcription factor XBP-1s binds to and transactivates Epstein-Barr virus BZLF1 promoter. J. Virol. 81: 13566-13577.
[Abstract]

2006

Berland R., Fernandez, L., Kari, E., Han, J.-H., Lomakin, I., Akira, S.,, Wortis, H.H., Kearney, J. F., Ucci, A. A., and Imanishi-Kari, T. 2006. TLR7-dependent loss of B cell tolerance in pathogenic autoantibody knock-in mice. Immunity 25: 64-75.
[Abstract]

Crowley, H., Alroy, J., Sproule, T. J., Roopenian, D., and Huber, B. T. 2006. The MHC class I-related FcRn ameliorates murine Lyme arthritis. Int. Immunol. 18: 409-414.
[Abstract]

Desgranges, Z. P. and Roy, A. L. 2006. TFII-I: connecting mitogenic signals to cell cycle regulation. Cell Cycle 5: 356-359.
[Abstract]

Ghosh, S., Seward, R., Costello, C. E., Stollar, B. D., and Huber, B. T. 2006. Autoantibodies from synovial lesions in chronic, antibiotic treatment-resistant Lyme arthritis bind cytokeratin-10. J. Immunol. 177: 2486-2494.
[Abstract]

Hakre, S., Tussie-Luna, M. I., Ashworth, T., Novina, C. D., Settleman, J., Sharp, P. A.and Roy, A. L. 2006 Opposing functions of TFII-I spliced isoforms in growth factor induced gene expression. Mol. Cell 24: 301-308.
[Abstract]

Hsiao, F. C., Lin, M., Tai, A., Chen, G., and Huber, B. T. 2006. Cutting edge: Epstein-Barr virus transactivates the HERV-K18 superantigen by docking to the human complement receptor 2 (CD21) on primary B cells. J. Immunol. 177: 2056-2060.
[Abstract]

Jacque, B., Stephan, K., Smirnova, I., Kim, B., Gilling, D., and Poltorak, A. 2006. Mice expressing high levels of soluble CD14 retain LPS in the circulation and are resistant to LPS-induced lethality. Eur. J. Immunol. 36: 1-10.
[Abstract]

Pawlitsky, I., Angeles, C. V., Siegel, A. M., Stanton, M. L., Riblet, R., and Brodeur, P. H. 2006. Identification of a candidate regulatory element within the 5' flanking region of the mouse Igh locus defined by pro-B cell specific hypersensitivity associated with binding of PU.1, Pax5, and E2A. J. Immunol. 176: 6839-6851.
[Abstract]

Rajaiya, J,, Nixon, J. C., Ayers, N., Desgranges, Z. P., Roy, A. L., and Webb, C. F. 2006. Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Mol. Cell. Biol. 26: 4758-4768.
[Abstract]

Tai, A.K,, Lin, M., Chang, F., Chen, G., Hsiao, F., Sutkowski, N., and Huber, B. T. 2006. Murine V⓷+ and V⓻+ T cell subsets are specific targets for the HERV-K18 Env superantigen. J. Immunol. 177: 3178-3184.
[Abstract]

2005

Baughn, L. B. and Rosenberg, N. 2005. Disruption of the Shc/Grb2 complex during Abelson virus transformation affects proliferation, but not apoptosis. J. Virol. 79:2325-2334.
[
Abstract]

Chen, G., Tai, A. K., Lin, M., Chang, F., Terhorst, C., and Huber, B. T. 2005. Signaling lymphocyte activation molecule-associated protein is a negative regulator of the CD8 T cell response in mice. J. Immunol. 175: 2212-2218.
[Abstract]

Desgranges, Z. P., Ahn, J., Lazebnik, M., Ashworth, T., Lee, C., Pestell, R. C., Rosenberg, N., Prives, C., and Roy, A. L. 2005. Inhibition of TFII-I-dependent cell cycle regulation by p53. Mol. Cell. Biol. 25, 10940-10952.
[Abstract]

Finger, E., Brodeur, P. H., Hernandez, H. J., and Stadecker, M. J. 2005. Expansion of CD4 T cells expressing a highly restricted TCR structure specific for a single parasite epitope correlates with high pathology in murine schistosomiasis. Eur. J. Immunol. 35: 2659-2669.
[Abstract]

Ghosh, S., Steere, A. C., Stollar, B. D., and Huber, B. T. 2005. In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium. J. Immunol. 174: 2860-2869.
[Abstract]

Guerau-de-Arellano, M., Alroy, J., Bullard, D., and Huber, B. T. 2005. Aggravated Lyme carditis in CD11a-/- and CD11c-/- mice. Inf. Immun. 73: 7637-7643.
[Abstract]

Guerau-de-Arellano M., Alroy, J., and Huber, B.T. 2005. β integrins control the severity of murine Lyme carditis. Inf. Immun. 73:3242-3250.
[Abstract]

Guerau-de-Arellano. M., and Huber, B. T. 2005. Chemokines and Toll-like receptors in Lyme disease pathogenesis. Trends Mol. Med. 11: 114-120.
[
Abstract]

Hong, M., Lin, M., Huang, J. M., Baumeister, P., Hakre, S., Roy, A. L., and Lee, A. S. 2005. Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: Role of TFII-I and its tyrosine phosphorylation. J. Biol. Chem. 280: 16821-16828.
[
Abstract]

Laichalk, L. L. and Thorley-Lawson, D. A. 2005. Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo. J. Virol. 79: 1297-1307.
[
Abstract]

Marchlik, E., Kalman, R., and Rosenberg, N. 2005. Decreased virus population diversity in p53 null mice infected with weakly oncogenic Abelson virus. J. Virol. 79: 11618-11626.
[
Abstract]

Pegtel, D. M., Subramanian, A., Sheen, T. S., Tsai, C. H., Golub, T. R., and Thorley-Lawson, D. A. 2005. Epstein-Barr-Virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis. J. Virol. 79: 15430-15442.
[Abstract]

Rutitzky, L. I., Hernandez, H. J., Yim, Y. S., Ricklan, D. E., Finger, E., Mohan, C., Peter, I., Wakeland, E. K., and Stadecker, M. J. 2005. Enhanced egg-induced immunopathology correlates with high IFN-γ in murine schistosomiasis: identification of two epistatic genetic intervals. J. Immunol. 174: 435-440.
[
Abstract]

Souza, T. A., Stollar, B. D., Sullivan, J. L., Luzuriaga, K., and Thorley-Lawson, D. A. 2005. Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells. Proc. Natl. Acad. Sci. USA 102: 18093-18098.
[Abstract]

Stanton, M. L. and Brodeur, P. H. 2005. Cutting edge: Stat5 mediates the IL-7-induced accessibility of a representative D-distal Vh gene. J. Immunol.174: 3164-3168.
[Abstract]

2004

Gong, L., Unnikrishnan, I., Raghavan, A., Parmar, K. and Rosenberg, N. 2004. Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells. J. Virol. 78: 1636-1644.
[Abstract]

Hochberg D. R., and Thorley-Lawson DA. 2004. Quantitative detection of viral gene expression in populations of Epstein-Barr virus-infected cells in vivo. Methods Mol. Biol. 292: 39-56.
[
Abstract]

Hochberg, D., Souza, T., Catalina, M., Sullivan, J. L., Luzuriaga, K., and Thorley-Lawson, D. A. 2004. Active infection with Epstein-Barr virus targets and overwhelms the peripheral memory B cell compartment with resting, latently infected cells. J. Virol. 78:5194-5204.
[
Abstract]

Hochberg, D., Middeldorp, J. M., Catalina, M., Sullivan, J. L., Luzuriaga, K., and Thorley-Lawson, D. A. 2004. Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo. Proc. Natl. Acad. Sci. USA 101: 239-244.
[
Abstract]

Mao, C., Jiang, L., Melo-Jorge, M., Puthenveetil, M., Zhang, X., Carroll, M. C. and Imanishi-Kari, T. 2004. T Cell-independent somatic hypermutation in murine B cells with an immature phenotype. Immunity, 20: 133-144.
[Abstract]

Mathur, J., and Waldor, M. K. 2004. The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides. Infect. Immun. 72: 3577-3583
[Abstract]

Pegtel, D. M., Middeldorp, J., and Thorley-Lawson, D. A. 2004. Epstein-Barr virus infection in ex vivo tonsil epithelial cell cultures of asymptomatic carriers. J. Virol. 78:12613-12624.
[
Abstract]

Sachs, Z., Sharpless, N. E., DePinho, R. A., and Rosenberg, N. 2004. p16Ink4a interferes with Abelson virus transformation by enhancing apoptosis. J. Virol. 78: 3304-3311.
[
Abstract]

Sacristan, C., Tussie-Luna, I., Logan, S. M., and Roy, A. L. 2004. Mechanism of Btk-mediated recruitment and regulation of TFII-I. J. Biol. Chem. 279: 7147-7158.
[Abstract]

Stadecker, M. J., Asahi, H., Finger, E., Hernandez, H. J., Rutitzky, L. I., and Sun, J. 2004. The immunobiology of Th1 polarization in high-pathology schistosomiasis. Immunol. Rev. 201: 168-179.
[
Abstract]

Sutkowski, N., Chen, G., Calderon, G., and Huber, B. T. 2004. Epstein-Barr virus latent membrane protein LMP2-A is sufficient for transactivation of the human endogenous retrovirus HERVK-18 superantigen. J. Virol. 78: 7852-7860.
[
Abstract]

Willet, T. A., Meyer, A. L., Brown, E. L., and Huber, B. T. 2004. An effective second-generation outer surface protein A-derived Lyme vaccine that eliminates a potentially autoreactive T cell epitope. Proc. Natl. Acad. Sci. USA 101: 1303-1308.
[
Abstract]

2003

Crowley, H. and Huber, B. T. 2003. Host-adapted Borrelia burgdorferi in mice express OspA during inflammation. Infect. Immun. 71: 40034010.
[Abstract]

Denis, M. and Huber, B. T. 2003. Native and recombinant interleukin-2, two functionally distinct molecules. Mol. Immunol. 40: 279-286.
[
Abstract]

Heilpern, A. J., and Waldor, M. K. 2003. pIIICTX, a predicted CTXφ minor coat protein, can expand the host range of coliphage fd to include Vibrio cholerae. J. Bacteriol 185: 1037-1044.
[Abstract]

Min, I. M., Schrader, C. E., Vardo, J., Luby, T. M., D'Avirro, N., Stavnezer, J., and Selsing, E. 2003. The sμ tandem repeat region is critical for Ig isotype switching in the absence of msh2. Immunity 19: 515-524.
[
Abstract]

Seward, R., von Haller, P., Aebersold, R., and Huber, B. T. 2003. Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis. Mol. Immunol. 39: 983-993.
[Abstract]

Warren, D. W., Griffin, D., Mainville, C. A., and Rosenberg, N. 2003. The carboxyl terminus of v-Abl mediates protein stability in pre-B lymphocytes. J. Virol. 77: 4617-4625.
[Abstract]

2002

Cheriyath, V., Desgranges, Z. P., and Roy, A. L. 2002. c-Src dependent transcriptional activation of TFII-I. J. Biol. Chem. 277: 22798-22805.
[Abstract]

Guerau-de-Arellano, M. and Huber, B. T. 2002. Development of autoimmunity in Lyme arthritis. Curr. Opin. Rheumatol. 14: 388-393.
[Abstract]

Laichalk, L., Hochberg, D., Babcock, G. J., Freeman, R. B., and Thorley-Lawson, D. A. 2002. The dispersal of mucosal memory B cells. Evidence from persistent EBV infection. Immunity 16:745-754.
[Abstract]

Tsai, H. F., D'Avirro, N., and Selsing, E. 2002. Gene conversion-like sequence transfers in a mouse antibody transgene: antigen selection allows sensitive detection of V region interactions based on homology. Int. Immunol. 14: 55-64.
[Abstract]

Tussie-Luna, M. I., Michel, B., Hakre, S., and Roy, A. L. 2002. The SUMO unbiquitin-protein isopeptide ligase family member Miz1/PIASxβ/Siz2 is a transcriptional co-factor for TFII-I family proteins. J. Biol. Chem. 277: 43185-43193.
[Abstract]

2001

Haines, B. B., Angeles, C. V., Parmelee, A. P., McLean, P. A., and Brodeur, P. H. 2001. Germline diversity of the expressed BALB/c VhJ558 gene family. Mol. Immunol. 38: 9-18.
[
Abstract]

Hsu, P. N., Wolf, P. R., Sutkowski, N., McLellan, B., Ploegh, H. L., and Huber, B. T. 2001. Association of MMTV superantigen with MHC class II during biosynthesis. J. Immunol. 166: 3309-3314.
[Abstract]

Li, J., Fernandez, L., O'Connor, K. C., Imanishi-Kari, T., Stollar, B. D. 2001. The rearranged V(H) domain of a physiologically selected anti-single-stranded DNA antidoby as a precursor for formation of IgM and IgG antibodies to diverse antigens. J. Immunol. 167: 3746-3755.
[Abstract]

Luby, T. M., Sigurdardottir, D., Berger, E. D., and Selsing, E. 2001. Sequences associated with the mouse Sμ switch region are important for immunoglobulin heavy chain transgene expression in B cell development. Eur. J. Immunol. 31 :2866-2875.
[Abstract]

Luby, T. M., Schrader, C. E., Stavnezer, J., and Selsing, E. 2001. The μ switch region tandem repeats are important, but not required, for antibody class switch recombination. J. Exp. Med. 193: 159-168.
[Abstract]

Mainville, C., Parmar, K., Unnikrishnan, I. Raffel G. D., Gong, L., and Rosenberg, N. 2001. Alteration of the FLVRES motif in the v-Abl SH2 domain confers a temperature sensitive transformation phenotype. J. Virol. 75:1816-1823.
[Abstract]

 


Last updated February 2008
Send comments to
Webmaster