Publications by Our Students 2004-Present

2009

Ashworth, T. and Roy, A. L. 2009. Phase specific function of the transcription factor TFII-I during cell cycle. Cell Cycle 8: 96-605.
[Abstract]

Caradonna, K., and PereiraPerrin, M. 2009. Preferential brain homing following intranasal administration of Trypanosoma cruzi. Inf. Immun. 77:1349-1356.
[Abstract]

Conner, J. R., Smirnova, I. I., Poltorak, A.2009. A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice. J. Exp. Med. 206:1615-1631.
[Abstract]

Cosmopoulos., K., Pegtel, M., Hawkins, J., Moffett, H., Novina, C., Middeldorp, J., and Thorley-Lawson D. A. 2009. Comprehensive profiling of EBV microRNAs in nasopharyngeal carcinoma. J. Virol. 83: 2357-2367.
[Abstract]

Eccleston, J., Schrader, C. E., Yuan, K., Stavnezer, J., and Selsing, E. 2009. Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats. J. Immunol. 183: 1222-1228.
[Abstract]

Hadinoto, V., Shapiro, M., Sun, C. C., and Thorley-Lawson, D. A.2009. The dynamics of EBV shedding implicate a central role for epithelial cells in amplifying viral output. PLoS Pathog. 5: e1000496.
[Abstract]

Losick, V. P., Stephan, K., Smirnova, I. I., Isberg, R. R., and Poltorak, A.2009. A hemidominant Naip5 allele in MOLF/Ei-derived macrophages restricts L. pneumophila intracellular growth. Inf. Inmmun. 77, 196-204.
[Abstract]

Mele, D. A., Bista, P., Baez, D. V., and Huber, B. T. 2009. Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence. Cell Cycle 9: Epub ahead of print
[Abstract]

Rockwell, K. R. and Huber, B. T. 2009. Biologically distinct conformations of Bcl-x can be resolved using 2D isoelectric focusing. Mol. Immunol. 46: 1605-1609.
[Abstract]

Roughan, J. E. and Thorley-Lawson, D. A. 2009. The intersection of Epstein-Barr virus with the germinal center. J. Virol. 83: 3968-3976.
[Abstract]

Shin, O. S., Miller, L. S., Modlin, R. L., Akira, S., Uematsu, S., and Hu, L. T. 2009. Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K. J. Immunol. 183: 491-498.
[Abstract]

Weinkauf, C., and PereiraPerrin, M. 2009. Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC. Inf. Immun. 77: 1368-1375.
[Abstract]

2008

Akpan, N., Caradonna, K., Chuenkova, M. V., and PereiraPerrin M. 2008. Chagas' disease parasite-derived neurotrophic factor activates cholinergic gene expression in neuronal PC12 cells. Brain Res. 1101, Epub ahead of print.
[Abstract]

Bazzone, L. E., Smith, P. M., Rutitzky, L. I., Shainheit, M. G., Urban, J. F., Setiawan, T., Blum A. M., Weinstock, J. V., and Stadecker, M. J. 2008. Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis. Infect. Immun. 76: 5164-5172.
[Abstract]

Blum, A., Setiawan, T., Hang, L., Stoyanoff, K., and Weinstock, J. V. 2008. IL12 and IL23 induction of substance P synthesis in murine T cells and macrophages is subject to IL10 and TGFβ regulation. Infect Immun. Epub ahead of print.
[Abstract]

Conner, J. R., Smirnova, I. I., and Poltorak, A. 2008. Forward genetic analysis of toll-like receptor responses in wild-derived mice reveals a novel anti-inflammatory role for IRAK1BP1. J. Exp. Med. 205: 305-314.
[Abstract]

Hadinoto, V., Shapiro, M., Greenough, T. C., Sullivan, J. L., Luzuriaga, K., and Thorley-Lawson, D. A. 2008. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood 111: 1420-1427.
[Abstract]

Iliopoulou, B. P., Alroy, J., and Huber, B. T. 2008. Persistent arthritis in Borrelia burgdorferi-infected HLA-DR4-positive CD28-negative mice post-antibiotic treatment. Arthritis Rheum. 58: 3892-3901.
[Abstract]

Iliopoulou, B. P., and Huber, B. T. 2008. Emergence of chronic Lyme arthritis: Putting the breaks on CD28 costimulation. Immunopharmacol Immunotoxicol. Epub ahead of print.
[Abstract]

Nguyen, K., Sylvain, N. R., and Bunnell, S. C. T-cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76. Immunity 28: 810-821.
[Abstract]

Rutitzky LI, Bazzone L, Shainheit MG, Joyce-Shaikh B, Cua DJ, Stadecker MJ. 2008. IL-23 is required for the development of severe egg-induced immunopathology in schistosomiasis and for lesional expression of IL-17. J Immunol. 180, 2486-2495.
[Abstract]

Shainheit, M. G., Smith, P. M., Bazzone, L. E., Wang, A. C., Rutitzky, L. I., and Stadecker, M. J. 2008. Dendritic cell IL-23 and IL-1 production in response to schistosome eggs induces Th17 cells in a mouse strain prone to severe immunopathology. J. Immunol. 181: 8559-8566.
[Abstract]

Shapiro, M., Duca, K. A., Lee, K., Delgado-Eckert, E., Hawkins, J., Jarrah, A. S., Laubenbacher, R., Polys, N. F., Hadinoto, V., and Thorley-Lawson, D. A. 2008. A virtual look at Epstein-Barr virus infection: simulation mechanism. J Theor Biol. 252, 633-648.
[Abstract]

Shin, O. S., Isberg, R. R., Akira, S., Uematsu, S., Behera, A. K. and Hu, L. T. 2008. Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction. Infect. Immun. 76: 2341-2351.
[Abstract]

2007

Ashworth, T. and Roy, A. L. 2007. Cutting Edge: TFII-I controls B cell proliferation via regulating NF-κB. J. Immunol. 178: 2631-2635.
[Abstract]

Budde, P. P., Davis, B. M., Yuan, J., and Waldor, M. K. 2007. Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. J. Bacteriol. 198: 491-500.
[Abstract]

Castiglione, F., Duca, K., Jarrah, A., Laubenbacher, R., Hochberg, D., and Thorley-Lawson, D. 2007. Simulating Epstein-Barr virus infection with C-ImmSim. Bioinformatics 23: 1371-1377.
[Abstract]

Chen, G., Tai, A. K., Lin, M., Chang, F., Terhorst, C., and Huber, B. T. 2007. Increased proliferation of CD8(+) T cells in SAP-deficient mice is associated with impaired activation-induced cell death. Eur. J. Immunol. 37: 663-674.
[Abstract]

de Melo-Jorge, M. and PereiraPerrin, M. 2007. The Chagas' Disease parasite Trypanosoma cruzi exploits nerve growth factor receptor TrkA to infect mammalian hosts. Cell Host & Microbe 1: 251-261.
[Abstract]

Duca, K. A., Shiprio, M., Delgado-Eckert, E., Hadinoto, V., Jarrah, A. S., Laubenbacher, R., Lee, K., Luzuriaga, K., Polys, N. F., and Thorley-Lawson, D. 2007. A vitrual look at Epstein-Barr virus infection: Biological interpretation. Plos Pathog. 3: 1388-1400.
[Abstract]

Ghosh, S. and Huber, B. T. 2007. Clonal diversification in OspA-specific antibodies from peripheral circulation of a chronic Lyme arthritis patient. J. Immunol. Methods. 321: 121-134.
[Abstract]

Hadinoto, V., Shapiro, M., Greenough, T. C., Sullivan, J. L., Luzuriago, K., and Thorley-Lawson, D. 2007. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood Epub ahead of print.
[Abstract]

Han, J. H., Akira, S., Calame, K., Beutler, B., Selsing, E., and Imanishi-Kari, T. 2007. Class switch recombination and somatic hypermutation in early mouse B Cells are mediated by B Cell and toll-like receptors. Immunity 27: 64-75.
[Abstract]

Huang, F. T., Yu, K., Balter, B. B., Selsing, E., Oruc, Z., Khamlichi, A. A., Hsieh, C. L., and Lieber, M. R. 2007. Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Sμ class switch region. Mol. Cell. Biol. 27: 5921-5932.
[Abstract]

Iliopoulou, B. P., Alroy, J., and Huber, B. T. 2007. CD28 Deficiency exacerbates joint inflammation upon Borrelia burgdorferi infection, resulting in the development of chronic Lyme arthritis. J. Immunol. 179: 8076-8082.
[Abstract]

Mathur, J., Davis, B. M, and Waldor, M. K. 2007. Antimicrobial peptides activate the Vibrio cholerae sigmaE regulon through an OmpU-dependent signalling pathway. Mol Microbiol. 63: 848-58.
[Abstract]

Pegtel, D. M., Subramanian, A., Merritt, D., Tsai, C. H., Sheen, T. S., Golub T. R., and Thorley-Lawson, D. A. 2007. IFN-α-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas. Cancer Res. 67: 474-481.
[Abstract]

Shainheit, M. G., Saraceno, R., Bazzone, L. E., Rutitzky, L. I., and Stadecker, M. J. 2007. Disruption of interleukin-27 signaling results in impaired gamma interferon production but does not significantly affect immunopathology in murine schistosome infection. Infect. Immun. 75: 3167-3177.
[Abstract]

Shin, S. O., Behera, A. K., Bronson, R. T., and Hu, L. T. 2007. Role of novel protein kinase C isoforms in Lyme arthritis. Cell. Microbiol. 9: 1987-1996.
[Abstract]

Stephan, K., Smirnova, I., Jacque, B., and Poltorak, A. 2007. Genetic analyses of the innate immune responses in wild-derived strains of mice. Eur. J. Immunol. 37: 212-223.
[Abstract]

Souza, T. A., Stollar, B. D., Sullivan, J. L., Luzuriaga, K., and Thorley-Lawson, D.A. 2007. Influence of EBV on the peripheral blood memory B cell compartment. J. Immunol. 179: 3153-3160.
[Abstract]

Sun, C. C. and Thorley-Lawson, D., 2007. Plasma cell-specific transcription factor XBP-1s binds to and transactivates Epstein-Barr virus BZLF1 promoter. J. Virol. 81: 13566-13577.
[Abstract]

2006

Berland R., Fernandez, L., Kari, E., Han, J.-H., Lomakin, I., Akira, S.,, Wortis, H.H., Kearney, J. F., Ucci, A. A., and Imanishi-Kari, T. 2006. TLR7-dependent loss of B cell tolerance in pathogenic autoantibody knock-in mice. Immunity 25: 64-75.
[Abstract]

Crowley, H., Alroy, J., Sproule, T. J., Roopenian, D., and Huber, B. T. 2006. The MHC class I-related FcRn ameliorates murine Lyme arthritis. Int. Immunol. 18: 409-414.
[Abstract]

Desgranges, Z. P. and Roy, A. L. 2006. TFII-I: connecting mitogenic signals to cell cycle regulation. Cell Cycle 5: 356-359.
[Abstract]

Ghosh, S., Seward, R., Costello, C. E., Stollar, B. D., and Huber, B. T. 2006. Autoantibodies from synovial lesions in chronic, antibiotic treatment-resistant Lyme arthritis bind cytokeratin-10. J. Immunol. 177: 2486-2494.
[Abstract]

Hakre, S., Tussie-Luna, M. I., Ashworth, T., Novina, C. D., Settleman, J., Sharp, P. A.and Roy, A. L. 2006 Opposing functions of TFII-I spliced isoforms in growth factor induced gene expression. Mol. Cell 24: 301-308.
[Abstract]

Hsiao, F. C., Lin, M., Tai, A., Chen, G., and Huber, B. T. 2006. Cutting edge: Epstein-Barr virus transactivates the HERV-K18 superantigen by docking to the human complement receptor 2 (CD21) on primary B cells. J. Immunol. 177: 2056-2060.
[Abstract]

Jacque, B., Stephan, K., Smirnova, I., Kim, B., Gilling, D., and Poltorak, A. 2006. Mice expressing high levels of soluble CD14 retain LPS in the circulation and are resistant to LPS-induced lethality. Eur. J. Immunol. 36: 1-10.
[Abstract]

Pawlitsky, I., Angeles, C. V., Siegel, A. M., Stanton, M. L., Riblet, R., and Brodeur, P. H. 2006. Identification of a candidate regulatory element within the 5' flanking region of the mouse Igh locus defined by pro-B cell specific hypersensitivity associated with binding of PU.1, Pax5, and E2A. J. Immunol. 176: 6839-6851.
[Abstract]

Rajaiya, J,, Nixon, J. C., Ayers, N., Desgranges, Z. P., Roy, A. L., and Webb, C. F. 2006. Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Mol. Cell. Biol. 26: 4758-4768.
[Abstract]

Tai, A.K,, Lin, M., Chang, F., Chen, G., Hsiao, F., Sutkowski, N., and Huber, B. T. 2006. Murine V⓷+ and V⓻+ T cell subsets are specific targets for the HERV-K18 Env superantigen. J. Immunol. 177: 3178-3184.
[Abstract]

2005

Baughn, L. B. and Rosenberg, N. 2005. Disruption of the Shc/Grb2 complex during Abelson virus transformation affects proliferation, but not apoptosis. J. Virol. 79:2325-2334.
[Abstract]

Chen, G., Tai, A. K., Lin, M., Chang, F., Terhorst, C., and Huber, B. T. 2005. Signaling lymphocyte activation molecule-associated protein is a negative regulator of the CD8 T cell response in mice. J. Immunol. 175: 2212-2218.
[Abstract]

Desgranges, Z. P., Ahn, J., Lazebnik, M., Ashworth, T., Lee, C., Pestell, R. C., Rosenberg, N., Prives, C., and Roy, A. L. 2005. Inhibition of TFII-I-dependent cell cycle regulation by p53. Mol. Cell. Biol. 25, 10940-10952.
[Abstract]

Finger, E., Brodeur, P. H., Hernandez, H. J., and Stadecker, M. J. 2005. Expansion of CD4 T cells expressing a highly restricted TCR structure specific for a single parasite epitope correlates with high pathology in murine schistosomiasis. Eur. J. Immunol. 35: 2659-2669.
[Abstract]

Ghosh, S., Steere, A. C., Stollar, B. D., and Huber, B. T. 2005. In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium. J. Immunol. 174: 2860-2869.
[Abstract]

Guerau-de-Arellano, M., Alroy, J., Bullard, D., and Huber, B. T. 2005. Aggravated Lyme carditis in CD11a-/- and CD11c-/- mice. Inf. Immun. 73: 7637-7643.
[Abstract]

Guerau-de-Arellano M., Alroy, J., and Huber, B.T. 2005. β integrins control the severity of murine Lyme carditis. Inf. Immun. 73:3242-3250.
[Abstract]

Guerau-de-Arellano. M., and Huber, B. T. 2005. Chemokines and Toll-like receptors in Lyme disease pathogenesis. Trends Mol. Med. 11: 114-120.
[Abstract]

Hong, M., Lin, M., Huang, J. M., Baumeister, P., Hakre, S., Roy, A. L., and Lee, A. S. 2005. Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: Role of TFII-I and its tyrosine phosphorylation. J. Biol. Chem. 280: 16821-16828.
[Abstract]

Laichalk, L. L. and Thorley-Lawson, D. A. 2005. Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo. J. Virol. 79: 1297-1307.
[Abstract]

Marchlik, E., Kalman, R., and Rosenberg, N. 2005. Decreased virus population diversity in p53 null mice infected with weakly oncogenic Abelson virus. J. Virol. 79: 11618-11626.
[Abstract]

Pegtel, D. M., Subramanian, A., Sheen, T. S., Tsai, C. H., Golub, T. R., and Thorley-Lawson, D. A. 2005. Epstein-Barr-Virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis. J. Virol. 79: 15430-15442.
[Abstract]

Rutitzky, L. I., Hernandez, H. J., Yim, Y. S., Ricklan, D. E., Finger, E., Mohan, C., Peter, I., Wakeland, E. K., and Stadecker, M. J. 2005. Enhanced egg-induced immunopathology correlates with high IFN-γ in murine schistosomiasis: identification of two epistatic genetic intervals. J. Immunol. 174: 435-440.
[Abstract]

Souza, T. A., Stollar, B. D., Sullivan, J. L., Luzuriaga, K., and Thorley-Lawson, D. A. 2005. Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells. Proc. Natl. Acad. Sci. USA 102: 18093-18098.
[Abstract]

Stanton, M. L. and Brodeur, P. H. 2005. Cutting edge: Stat5 mediates the IL-7-induced accessibility of a representative D-distal Vh gene. J. Immunol.174: 3164-3168.
[Abstract]

2004

Gong, L., Unnikrishnan, I., Raghavan, A., Parmar, K. and Rosenberg, N. 2004. Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells. J. Virol. 78: 1636-1644.
[Abstract]

Hochberg D. R., and Thorley-Lawson DA. 2004. Quantitative detection of viral gene expression in populations of Epstein-Barr virus-infected cells in vivo. Methods Mol. Biol. 292: 39-56.
[Abstract]

Hochberg, D., Souza, T., Catalina, M., Sullivan, J. L., Luzuriaga, K., and Thorley-Lawson, D. A. 2004. Active infection with Epstein-Barr virus targets and overwhelms the peripheral memory B cell compartment with resting, latently infected cells. J. Virol. 78:5194-5204.
[Abstract]

Hochberg, D., Middeldorp, J. M., Catalina, M., Sullivan, J. L., Luzuriaga, K., and Thorley-Lawson, D. A. 2004. Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo. Proc. Natl. Acad. Sci. USA 101: 239-244.
[Abstract]

Mao, C., Jiang, L., Melo-Jorge, M., Puthenveetil, M., Zhang, X., Carroll, M. C. and Imanishi-Kari, T. 2004. T Cell-independent somatic hypermutation in murine B cells with an immature phenotype. Immunity, 20: 133-144.
[Abstract]

Mathur, J., and Waldor, M. K. 2004. The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides. Infect. Immun. 72: 3577-3583
[Abstract]

Pegtel, D. M., Middeldorp, J., and Thorley-Lawson, D. A. 2004. Epstein-Barr virus infection in ex vivo tonsil epithelial cell cultures of asymptomatic carriers. J. Virol. 78:12613-12624.
[Abstract]

Sachs, Z., Sharpless, N. E., DePinho, R. A., and Rosenberg, N. 2004. p16Ink4a interferes with Abelson virus transformation by enhancing apoptosis. J. Virol. 78: 3304-3311.
[Abstract]

Sacristan, C., Tussie-Luna, I., Logan, S. M., and Roy, A. L. 2004. Mechanism of Btk-mediated recruitment and regulation of TFII-I. J. Biol. Chem. 279: 7147-7158.
[Abstract]

Stadecker, M. J., Asahi, H., Finger, E., Hernandez, H. J., Rutitzky, L. I., and Sun, J. 2004. The immunobiology of Th1 polarization in high-pathology schistosomiasis. Immunol. Rev. 201: 168-179.
[Abstract]

Sutkowski, N., Chen, G., Calderon, G., and Huber, B. T. 2004. Epstein-Barr virus latent membrane protein LMP2-A is sufficient for transactivation of the human endogenous retrovirus HERVK-18 superantigen. J. Virol. 78: 7852-7860.
[Abstract]

Willet, T. A., Meyer, A. L., Brown, E. L., and Huber, B. T. 2004. An effective second-generation outer surface protein A-derived Lyme vaccine that eliminates a potentially autoreactive T cell epitope. Proc. Natl. Acad. Sci. USA 101: 1303-1308.
[Abstract]