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Jill Roughan,
B. S., Biology, EBV is present in >95% of adults and persists
in B lymphocytes. To do this the virus uses a series of different
gene expression patterns to manipulate the infected B cells
to undergo normal differentiation into memory cells. Part
of this process involves the migration of the B cells through
different compartments of secondary lymphoid tissue. This
migration is mediated by chemokine interaction with specific
receptors on the B cell. To gain insight into how EBV manipulates
the movement of infected B cells we are attempting to define
which chemokine receptors are expressed on different subsets
of infected B cells in vivo and how responsive they are to
different chemokines.. |
