Selected Publications

Petridis, M., Bagdasarian, M., Waldor, M. K., and Walker, E. 2006. Horizontal transfer of Shiga toxin and antibiotic resistance genes among Escherichia coli strains in house fly (Diptera: Muscidae) gut. J. Med Entomol. 43: 288-295.
[Abstract]

Burrus, V., Quezada-Calvillo, R., Marrero, J., and Waldor, M. K. 2006. SXT-related integrating conjugative element in New World Vibrio cholerae. Appl. Environ. Microbiol. 72: 3054-3057.
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Burrus, V., Marrero, J., and Waldor, M. K. 2006. The current ICE age: Biology and evolution of SXT-related integrating conjugative elements. Plasmid Epub ahead of print.
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Quinones, M., Davis, B. M., and Waldor, M. K. 2006. Activation of the Vibrio cholerae SOS response is not required for intestinal cholera toxin production or colonization. Infect Immun. 74: 927-930.
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Waldor, M. K. 2006. Disarming pathogens -- a new approach for antibiotic development. N.Engl. J. Med. 354: 296-297.
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Egan, E. S., Duigou, S., and Waldor, M. K. 2006. Autorepression of RctB, an initiator of Vibrio cholerae chromosome II replication. J. Bacteriol. 188: 789-793.
[Abstract]

Livny, J., Fogel, M. A., Davis, B. M., and Waldor, M. K. 2005. sRNAPredict: an integrative computational approach to identify sRNAs in bacterial genomes. Nucleic Acids Res. 33: 4096-4105.
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Waldor, M. K. and Friedman, D. I. 2005. Phage regulatory circuits and virulence gene expression. Current Opin. Microbiol. 8: 459-465.
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McLeod, S. M., Kimsey, H. H., Davis, B. M., and Waldor, M. K. 2005. CTXφ and Vibrio cholerae: exploring a newly recognized type of phage-host cell relationship. Mol. Microbiol. 57: 347-356.
[Abstract]

Davis, B. M., Quinones, M., Pratt, J., Ding, Y., and Waldor, M. K. 2005. Characterization of the small untranslated RNA RyhB and its regulon in Vibrio cholerae. J. Bacteriol. 187: 4005-4014.
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Marrero, J., and Waldor, M. K. 2005. Interactions between Inner Membrane Proteins in Donor and Recipient Cells Limit Conjugal DNA Transfer. Dev. Cell. 8: 963-970.
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Egan, E. S., Fogel, M. A., and Waldor, M. K. 2005. Divided genomes: negotiating the cell cycle in prokaryotes with multiple chromosomes. Mol. Microbiol. 56: 1129-1138.
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Ritchie, J. M., and Waldor, M. K. 2005. The locus of enterocyte effacement-encoded effector proteins all promote enterohemorrhagic Escherichia coli pathogenicity in infant rabbits. Infect. Immun. 73: 1466-1474.
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Quinones, M., Kimsey, H. H., and Waldor, M. K. 2005. LexA cleavage Is required for CTX prophage induction. Mol. Cell 17: 291-300.
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Fogel, M. A. and Waldor, M. K. 2005. Distinct segregation dynamics of the two Vibrio cholerae chromosomes. Mol. Microbiol. 55: 125-136.
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McLeod, S. M. and Waldor, M. K. 2004. Characterization of XerC- and XerD-dependent CTX phage integration in Vibrio cholerae. Mol. Microbiol. 54: 935-947.
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Beaber, J. W. and Waldor, M. K. 2004. Identification of operators and promoters that control SXT conjugative transfer. J. Bacteriol. 186: 5945-5949.
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Egan, E. S., Lobner-Olesen, A., and Waldor, M. K. 2004. Synchronous replication initiation of the two Vibrio cholerae chromosomes. Curr. Biol. 14: R501-502.

Ding, Y., Davis, B. M., and Waldor, M. K. 2004. Hfq is essential for Vibrio cholerae virulence and downregulates sigma expression. Mol. Microbiol. 53: 345-354.
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Burrus, V. and Waldor, M. K. 2004. Shaping bacterial genomes with integrative and conjugative elements. Res. Microbiol. 155: 376-386.
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Mathur, J., and Waldor, M. K. 2004. The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides. Infect. Immun. 72: 3577-3583
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Burrus, V. and Waldor, M. K. 2004. Formation of SXT tandem arrays and SXT-R391 hybrids. J. Bact. 186: 2636-2645.
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Beaber, J. W., Hochhut, B., and Waldor, M. K. 2004. SOS response promotes horizontal dissemination of antibioltic resistance genes. Nature 427: 72-74.
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Kimsey, H. H. and Waldor, M. K. 2004. The CTXφ repressor RstR binds DNA cooperatively to form tetrameric repressor-operator complexes. J. Biol. Chem. 279: 2640-2647.
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Ritchie, J. M., Thorpe, C. M., Rogers, A. B., and Waldor, M. K. 2003. Critical roles for stx2, eae, and tir in enterohemorrhaic Escherichia coli-induced diarrhea and interstinal inflammation in infant rabbits. Inf. Immun. 71: 7129-7139.
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Sumby, P. and Waldor, M. K. 2003. Transcription of the toxin genes present within the staphylococcal phage φSa3ms is intimately linked with the phage's life cycle. J. Bacteriol. 185: 6841-6851.
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Egan, E. S., and Waldor, M. K. 2003. Distinct replication requirements for the two Vibrio cholerae chromosomes. Cell 114: 521-530.
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Burrus, V., and Waldor, M. K. 2003. Control of SXT integration and excitions. J. Bacteriol. 185: 5045-5054.
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Ding, Y., and Waldor, M. K. 2003. Deletion of a Vibrio cholerae CIC channel results in acid sensitivity and enhanced intestinal colonization. Infect. Immun. 71: 4197-4200.
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Davis, B. M., and Waldor, M. K. 2003. Filamentous phases linked to virulence of Vibrio cholerae. Curr. Opin. Microbiol. 6: 35-42.
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Ritchie, J. M., Wagner, P. L., Acheson, D. W., and Waldor, M. K. 2003. Comparison of Shiga toxin production by hemolytic-wremic syndrome-associated and bovine associated Shiga toxin-producing Escherichia coli isolates. Appl. Environ. Microbiol. 69: 1059-1066.
[Abstract]

Heilpern, A. J., and Waldor, M. K. 2003. pIIICTX, a predicted CTXφ minor coat protein, can expand the host range of coliphage fd to include Vibrio cholerae. J. Bacteriol 185: 1037-1044.
[Abstract]

Wagner, P. L.,Livny, J., Neely, M. N., Acheson, D. W., Friedman, D. I., and Waldor, M. K. 2002. Bacteriophage control of Shiga toxin 1 production and relase by Escherichia coli. Mol. Microbiol. 44: 957-970.
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Huber, K. E., and Waldor, M. K. 2002. Filamentous phage integration requires the host recombinases XerC and XerD. Nature 417: 656-659.
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Boyd, E. F., and Waldor, M. K. 2002. Evolutionary and functional analyses of variatns of toxin-coregulated pilus protein TcpA from toxigenic Vibrio cholerae nonO1/nonO139 serogroup isolates. Micrbiology 148: 1655-1666.
[Abstract]

Beaber, J. W., Hochhut, B., and Waldor, M. K. 2002. Genomic and functional analyses of SXT, an integrating antibiotic resistance gene transfer element derived from Vibrio cholerae. J. Bacteriol. 184: 4259-4269.
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Wagner, P. L., and Waldor, M. K. 2002. Bacteriophage control of bacterial virulence. Infect. Immun. 70: 3985-3993.
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Davis, B. M., Kimsey, H. H., Kane, A. V., and Waldor, M. K. 2002. A satellite phage-encoded antirepressor induces repressor aggregation and choloera toxin gene transfer. EMBO J. 21: 4240-4249.
[Abstract]

Beaber, J. W., Burrus, Hochhut, B., and Waldor, M. K. 2002. Comparison of SXT and R391, two conjugative integrating elements: definition of a genetic backbone for the mobilization of resistance determinants. Cell. Mol. Life Sci. 59: 2065-2070.
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Hochhut, B., Lotfi, Y., Mazel, D., Faruque, S. M., Woodgate, R., and Waldor, M. K. 2001. Molecular analysis of antibiotic resistance gene clusters in Vibrio cholerae O139 and O1 SXT constins. Antimicrob Agents Chemother. 45: 2991-3000.
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Moyer, K. E., Kimsey, H. H., and Waldor, M. K. 2001. Evidence for a rolling-circle mechanism of phage DNA synthesis from both replicative and integrated forms of CTXφ. Mol. Microbiol. 41: 311-323.
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Wagner, P. L., Neely, M. N., Zhang, X., Acheson, D. W., Waldor, M. K., and Friedman, D. I. 2001. Role for a phage promoter in Shiga toxin 2 expression from a pathogenic Escherichia coli strain. J. Bacteriol. 183: 2081-2085.
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Wagner, P. L., Acheson, D. W., and Waldor, M. K. 2001. Human neutrophils and their products induce Shiga toxin production by enterohemorrhagic Escherichia coli. Infect. Immun. 69: 1934-1937.
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Hochhut, B., Beaber, J. W., Woodgate, R., and Waldor, M. K. 2001. Formation of chromosomal tandem arrays of the SXT element and R391, two conjugative chromosomally integrating elements that share an attachment site. J. Bacteriol. 183: 1124-1132.
[Abstract]