Selected Publications

Blum, A., Setiawan, T., Hang, L., Stoyanoff, K., and Weinstock, J. V. 2008. IL12 and IL23 induction of substance P synthesis in murine T cells and macrophages is subject to IL10 and TGFβ regulation. Infect Immun. Epub ahead of print.
[Abstract]

Bandukwala ,H. S., Clay, B. S., Tong, J., Mody, P. D., Cannon, J. L., Shilling, R. A., Verbeek, J. S., Weinstock, J. V., Solway, J., and Sperling, A. I. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J. Exp. Med. 204: 1875-1889.
[Abstract]

Setiawan, T., Metwali, A., Blum, A. M., Ince, M. N., Urban, J. F., Jr., Elliott, D. E., and Weinstock, J. V. 2007. Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine. Infect. Immun. 75: 4655-4663.
[Abstract]

Elliott, D. E., Summers, R. W., and Weinstock, J. V. 2007. Helminths as governors of immune-mediated inflammation. Int J Parasitol. 37: 457-464.
[Abstract]

Weinstock, J. V. 2006. Helminths and mucosal immune modulation. Ann. N. Y. Acad. Sci. 1072: 356-364.
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Reinke, E. K., Johnson, M. J., Ling, C., Karman, J., Lee, J., Weinstock, J. V., Sandor, M., and Fabry, Z. 2006. Substance P receptor mediated maintenance of chronic inflammation in EAE. J. Neuroimmunol. 180: 117-125.
[Abstract]

Kitagaki, K., Businga, T. R., Racila, D., Elliott, D. E., Weinstock, J. V., and Kline, J. N. 2006. Intestinal helminths protect in a murine model of asthma. J Immunol. 177: 1628-1635.
[Abstract]

Metwali, A., Setiawan, T., Blum, A. M., Urban J., Elliott, D. E., Hang, L., and Weinstock, J. V.2006. Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G253-259.
[Abstract]

Guarner, F., Bourdet-Sicard, R., Brandtzaeg, P., Gill, H. S., McGuirk, P., van Eden, W., Versalovic, J., Weinstock, J. V., and Rook, G. A. Mechanisms of disease: the hygiene hypothesis revisited. Nat Clin Pract Gastroenterol Hepatol. 2006. 3:275-284.
[Abstract]

Tong, J., Bandulwala, H. S., Clay, B. S., Anders, R. A., Shilling, R. A., Balachandran, D. D., Chen, B., Weinstock, J. V., Solway, J., Hamann, K. J., and Sperling, A. I. 2006. Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma. J Exp Med. 2006 May 15;203(5):1173-84. Epub ahead of print.
[Abstract]

Ince, M. N., Elliott, D. E., Setiawan, T., Blum, A., Metwali, A., Wang, Y., Urban, J. F., Jr. and Weinstock, J. V. 2006. Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFβ after lipopolysaccharide stimulation. J. Immunol.(Cutting Edge) 176: 726-729.
[Abstract]

Summers, R. W., Elliott, D. E., and Weinstock, J. V. 2005. Is there a role for helminths in the therapy of inflammatory bowel disease? Nat. Clin. Pract. Gastroenterol. Hepatol. 2: 62-63.
[Abstract]

Hyun, J. G., Lee, G., Brown, J. B., Grimm, G. R., Tang, Y., Mittal, N., Dirisina, R., Zhang, Z., Fryer, J. P., Weinstock, J. V., Luster, A. D., and Barrett, T. A. 2005. Anti-interferon-inducible chemokine, CXCL10, reduces colitis by impairing T helper-1 induction and recruitment in mice. Inflamm. Bowel Dis. 11: 799-805.
[Abstract]

Summers, R. W., Elliott, D. E., and Weinstock, J. V. 2005. Why Trichuris suis should prove safe for use in inflammatory bowel diseases. Inflamm. Bowel Dis.11: 783-784.
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Weinstock, J. V., Summers, R. W., and Elliott, D. E. 2005. Role of helminths in regulating mucosal inflammation. Springer Semin. Immunopathol. 27: 249-271.
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Summers, R. W., Elliott, D. E., Urban, J. F., Jr, Thompson, R. A., and Weinstock, J. V. 2005. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology 128: 825-832.
[Abstract]

Arsenescu, R., Blum, A. M., Metwali, A., Elliott, D. E., and Weinstock, J. V. 2005. IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation. J. Immunol. 174: 3906-3911.
[Abstract]

Elliott, D. E., Summers, R. W., and Weinstock, J. V. 2005. Helminths and the modulation of mucosal inflammation. Curr. Opin. Gastroenterol. 21: 51-58.
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Summers, R. W., Elliott, D. E., Urban, J. F., Jr, Thompson, R., and Weinstock, J. V. 2005. Trichuris suis therapy in Crohn's disease. Gut 54: 87-90.
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Elliott, D. E., Setiawan, T., Metwali, A., Blum, A., Urban, J. F., Jr., and Weinstock JV. 2004. Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice. Eur. J. Immunol. 34: 2690-2698.
[Abstract]

Metwali, A., Blum, A. M., Elliott, D. E., Setiawan, T., and Weinstock, J. V. 2004. Cutting edge: Hemokinin has substance P-like function and expression in inflammation. J. Immunol. 172: 6528-6532.
[Abstract]

Weinstock, J. V. 2004. The role of substance P, hemokinin and their receptor in governing mucosal inflammation and granulomatous responses. Front. Biosci. 9: 1936-1943.
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Weinstock, J. V., Summers, R., and Elliott, D. E. 2004. Helminths and harmony. Gut 53: 7-9
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Lo, J. C., Chin, R. K., Lee, Y., Kang, H. S., Wang, Y., Weinstock, J. V., Banks, T., Ware, C. F., Franzoso, G., and Fu, Y. X. 2003. Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J Clin Invest. 112: 1495-1505.
[Abstract]

Zavros, Y., Rathinavelu, S., Kao, J. Y., Todisco, A., Del Valle, J., Weinstock, J. V., Low, M. J., and Merchant, J. L. 2003. Treatment of Helicobacter gastritis with IL-4 requires somatostatin. Proc. Natl. Acad. Sci. USA 100: 12944-12949.
[Abstract]

Weinstock, J. V., Blum, A., Metwali, A., Elliott, D., Bunnett, N., and Arsenescu, R. 2003. Substance P regulates Th1-type colitis in IL-10 knockout mice. J. Immunol. 171: 3762-3767.
[Abstract]

Summers, R. W., Elliott, D. E., Qadir, K., Urban, J. F., Jr., Thompson, R., and Weinstock, J. V. 2003. Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease. Am. J. Gastroenterol. 98: 2034-2041.
[Abstract]

Elliott, D. E., Li, J., Blum, A., Metwali, A., Qadir, K., Urban, J. F., Jr., Weinstock, J. V. 2003. Exposure to schistosome eggs protects mice from TNBS-induced colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 284: G385-91.
[Abstract]

Blum, A. M., Metwali, A., Elliott, D. E., and Weinstock, J. V. 2003. T cell substance P receptor governs antigen-elicited IFN-γ production. Am. J. Physiol. Gastrointest. Liver Physiol. 284: G197-204.
[Abstract]

Robinson, P., Okhuysen, P. C., Chappell, C. L., Weinstock, J. V., Lewis, D. E., Actor, J. K., and White, A. C., Jr. 2003. Substance P expression correlates with severity of diarrhea in cryptosporidiosis. J. Infect. Dis. 188: 290-296.
[Abstract]

Weinstock, J. V., Blum, A., Metwali, A., Elliott, D., and Arsenescu, R. 2003. IL-18 and IL-12 signal through the NF-κB pathway to induce NK-1R expression on T cells. J. Immunol. 170: 5003-5007.
[Abstract]

Elsawa, S. F., Taylor, W., Petty, C. C., Marriott, I., Weinstock, J. V., and Bost, K. L. 2003. Reduced CTL response and increased viral burden in substance P receptor-deficient mice infected with murine gamma-herpesvirus 68. J. Immunol. 170: 2605-2612.
[Abstract]

Sandor, M., Weinstock, J. V., and Wynn, T. A. 2003. Granulomas in schistosome and mycobacterial infections: a model of local immune responses. Trends Immunol. 24: 44-52.
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Hogan, L. H., Wang, M., Suresh, M., Co, D.O., Weinstock, J. V., and Sandor, M. 2002. CD4+ TCR repertoire heterogeneity in Schistosoma mansoni-induced granulomas. J. Immunol. 169: 6386-6393.
[Abstract]

Berg, D. J., Zhang, J., Weinstock, J. V., Ismail, H. F., Earle, K. A., Alila, H., Pamukcu, R., Moore, S., and Lynch, R. G. 2002. Rapid development of colitis in NSAID-treated IL-10-deficient mice. Gastroenterology. 123: 1527-1542.
[Abstract]

Metwali A., Blum, A., Elliott, D. E., and Weinstock J. V. 2002. Interleukin-4 receptor α chain and STAT6 signaling inhibit γ interferon but not Th2 cytokine expression within schistosome granulomas. Infect. Immun. 70: 5651-5658
[Abstract]

Sacco, R., Hagen, M., Sandor, M., Weinstock, J. V., and Lynch, R. G. 2002. Established T(H1) granulomatous responses induced by active Mycobacterium avium infection switch to T(H2) following challenge with Schistosoma mansoni. Clin. Immunol. 104: 274-281.
[Abstract]

Weinstock, J. V., Summers, R. W., Elliott, D. E., Qadir, K., Urban, J. F., Jr., and Thompson, R. 2002. The possible link between de-worming and the emergence of immunological disease. J. Lab. Clin. Med. 139: 334-338.
[Abstract]

Metwali, A., Blum, A. M., Elliott, D. E., and Weinstock, J. V. 2002. IL-4 inhibits vasoactive intestinal peptide production by macrophages. Am. J. Physiol. Gastrointest. Liver Physiol. 283: G115-121.
[Abstract]