Structural & Membrane Biology

Researchers in this area are studying molecular structures using NMR, X-ray crystallography, and other techniques. Examples of areas of study include the role of EH domains in endocytosis, the structure of poly-A polymerase, and the interaction between src homology 2 domain ligands. Other researchers in this area study aspects of membrane structure and function including ion channels, the vacuolar proton pump, binding of polypeptide hormones to their receptors, and cholesterol movement within cells.

Research Laboratories

Peter Bullock - Initiation of DNA replication
Bill Bachovchin - Serine proteinases: structure, mechanism and biological functions
James Baleja - Molecular recognition; structure-based drug design
Robert Blaustein - Structure and function of voltage-gated potassium channels
Andrew Bohm - Structure of anthrax toxin and RNA processing complexes
Daniel Cox - Biophysical properties of the large-conductance Ca2+-activated K+ channel
Kathleen Dunlap - Modulation and physiological function of voltage-dependent channels
Michael Forgac - Mechanism of regulation of vacuolar acidification
David Greenblatt - Mechanisms of drug absorption; regulation and prediction of drug diffusion and/or transport; drug metabolism and biotransformation
Alan S. Kopin - Peptide and biogenic amine receptor structure and function
Athan Kuliopulos - Signal transduction of peptide receptors
Krishna Kumar - De novo protein design, cell surface engineering, and protein evolution
Laura Liscum - Intracellular cholesterol transport and metabolism
Michael Rosenblatt - Structural biology of hormone-receptor interactions; mechanisms of cancer metastasis to bone
Brian Schaffhausen - Mechanism of neoplastic transformation
Gavin Schinitzler - Role of chromatin remodeling complexes in transcriptional control