Signal
Transduction & Proliferation
The ability of cells to respond to their
environment is crucial for cell survival and for the regulation
of specialized cell functions. Cells respond to signals such
as growth factors by regulating signal transduction pathways.
Research in this area includes molecular recognition between
hormones and receptors, mechanisms of activation of JAK/STAT
transcriptional factors, pathways that regulate programmed
cell death, and intracellular regulators of proteolytic pathways.
Research Laboratories
Robert
Blaustein - Structure and function of voltage-gated potassium
channels
Brent
Cochran - Cell
growth regulation
Alexi
Degterev - Basic mechanisms of programmed cell death
James
Dice - Regulation of a lysosomal pathway
of proteolysis called chaperone-mediated autophagy
Thomas
Ducibella - Mammalian
oocyte maturation and in vitro fertilization
Larry
Feig - Signal
transduction pathways mediated by RAS and related GTPases
Ira
Herman - Signaling microvascular morphogenesis: control
of capillary growth and remodeling during development and
disease
Dan
Jay - Molecular
mechanisms of axon guidance and nerve growth cone motility
Peter
Juo – Localization and regulation of synaptic proteins
David Kaplan - Carcinogenesis and vascular disease
Richard
Karas - Effect of estrogen on
the cardiovascular system
Athan
Kuliopulos - Signal
transduction of peptide receptors
John
Kyriakis - Effect of growth,
inflammatory and stress stimuli on cell function
Andrew
Leiter - Transcriptional
regulation of development
Janis
Lem - Photoreceptors and retinal disease mechanisms
Laura
Liscum - Intracellular cholesterol transport and metabolism
Douglas Losordo - Translation of cell culture and animal
model experiments into clinical trials of therapeutic angiogenesis
Michael
Mendelsohn - Molecular
signaling mechanisms in vascular cells
Dmitri
Nurminsky - Transcriptional regulation in spermatogenesis
Michael Rosenblatt -
Structural biology of hormone-receptor interactions; mechanisms of cancer metastasis
to bone
Gary Sahagian -
Lysosomal trafficking and its role in breast cancer
Brian
Schaffhausen - Mechanism
of neoplastic transformation
Gavin
Schinitzler - Chromatin
remodeling complexes in transcriptional control
Amy
Simon - Molecular mechanisms affecting
asthma
Howard
Surks - Mechanisms that regulate vascular smooth muscle
cell contraction and relaxation
Theoharis
Theoharides - Mast cell stimulus-response coupling
Richard
Van Etten - Role of dysregulated oncogene function in
human leukemia
Amy
Yee - Molecular
mechanisms of transcriptional regulation |
