Molecular Microbiology 201: Tutorial in Basic Molecular Biology. Small group discussion designed to acquaint beginning students with central concepts and experimental tools. Limited to first-year students.

Molecular Microbiology 202: Experiments in Molecular Biology. An intensive laboratory course in which students are tutored individually by faculty members in the research laboratory. Emphasis is on experimental design and theoretical aspects of the research problems under investigation in the various laboratories.

Molecular Microbiology 206: Molecular Biology of Episomes and Plasmids. Fundamental properties of F-factors and drug resistance factors. Role of transposons in antibiotic resistance and plasmid evolution. Detailed examination of DNA processing for transfer in prokaryotic systems. Regulatory mechanisms for fertility, replication, and incompatibility. Use of plasmids in genetic engineering.

Molecular Microbiology 207B: Microbial Physiology and Differentiation. Cellular controls of biosynthesis of DNA, RNA, and proteins; the kinetics of cell division in bacteria; regulation of metabolism; and bacterial differentiation as a model system for development in higher organisms. Emphasis will be placed on the global regulatory mechanisms responsible for the control of gene expression.

Molecular Microbiology 214: Animal Virology. A general course with emphasis on the molecular aspects of viral replication and host cell interactions. Topics include virion structure, mechanisms of nucleic acid replication, transcription and translation; virion assembly and release; genetics; mechanisms of transformation by oncogeneic viruses; responses of the host to viral infectin, tumor viruses, and tumor cells; and mechanisms of persistent and slow virus infections. Prerequisites; a course in molecular biology or working knowledge of molecular techniques.

Molecular Biology 216: Foundations of Molecular Biology. An introduction to basic properties of the microbial systems employed in molecular biology, followed by the presentation of selected experimental models. Prerequisite: Biology 111-112 or equivalent and consent of the instructor. Designed for medical students; suitable for graduate students in other programs.

Molecular Microbiology 218: Foundations of Medical Microbiology. A survey of pathogenic microbiology, including general concepts of host-parasite interactions and specific examples of pathogenic bacteria, viruses, fungi, and animal parasites. Prerequisite: basic knowledge of microbiology and immunology and consent of the instructor. Designed for medical students; suitable for graduate students in other programs.

Molecular Microbiology 220: Genetic Analysis. A survey course with an emphasis on the application of genetic techniques to the study of both eukaryotic and prokaryotic organisms and their viruses. Students are introduced to genetic approaches through a combination of problem solving, group discussion, and lectures. Student presentations of classical and modern research papers are used to familiarize the class with the manner in which genetic approaches can be applied experimentally.

Molecular Microbiology 222: Mechanisms of Pathogenesis. The goal of this course is to familiarize students with current work in the field of bacterial pathogenesis. This course emphasizes the most current research and trends in the field. A secondary goal is to encourage students to develop a critical sense when analyzing primary research, as well as to develop oral skills and an ability to "think on their feet."

Molecular Microbiology 275: Applied Ethics for Scientists. A discussion/seminar course that treats selected topics related to ethical behavior in scientific work. Topics covered include fraud, plagiarism, data selection and analysis, record keeping, animal welfare, personnel issues, genetic screening and gene therapy, and conflict of interest. Enrollment restricted to third- and fourth-year graduate students.

Molecular Microbiology 291, 292: Graduate Seminar. Weekly reports of ongoing research given and attended by all members of the molecular microbiology program, including students, faculty, and postdoctoral fellows.

Molecular Microbiology 293, 294: Special Topics: Journal Club. In-depth study and discussion of specific topics through critical review of current literature in a small group format.

Molecular Microbiology 294E: Biology of Simple Eukaryotes. The goal of this course is to explore the ways in which simple eukaryotes, particularly fungi, can serve as powerful model organisms for the study of conserved eukaryotic biological processes. The course will focus on recent research that is helping to reveal mechanisms of fundamental processes such as chromosome segregation, control of cell division, establishment of cellular polarity and architecture, secretion, and developmental decisions. The course will feature a lecture/discussion/student presentation format.

Molecular Microbiology 297, 298: Graduate Research. Guided research on a topic suitable for a doctoral dissertation.


Tufts University Sackler School of Graduate Biomedical Sciences
Program in Molecular Microbiology
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