Camilli Laboratory
Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111
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Ayman Ismail
Postdoctoral Fellow
Ph.D.,University of Texas Southwestern Medical Center at Dallas
Thesis Topic
Biochemical reconstitution and functional characterization of the WAVE Regulatory Complex
Mechanism of WASP family proteins hyperactivation through oligomerization
Current Research
c-di-GMP is a second messenger implicated in the regulation of a variety of biological processes in Vibrio Cholerae, including virulence, motility and biofilm formation. I am interested in understanding how Vibrio Cholerae translates c-di-GMP signaling. More specifically, I am trying to determine in which way c-di-GMP changes the function of the proteins it binds to.
Publications
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Ismail, A.M., Padrick, S.B., Chen, B., Umetani, J., Rosen, M.K. (2009). The WAVE regulatory complex is inhibited. Nature structural and molecular biology 16, 561-563. WEB LINK
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Padrick, S.B.*, Cheng, H.C.*, Ismail, A.M.*, Panchal, S.C., Doolittle, L.K., Kim, S., Skehan, B.M., Umetani, J., Brautigam, C.A., Leong, J.M., and Rosen, M.K. (2008). Hierarchical regulation of WASP/WAVE proteins. Mol Cell 32, 426-438. (*, authors contributed equally). WEB LINK
- Talhouk, R.S., Mroue, R., Mokalled, M., Abi-Mosleh, L., Nehme, R., Ismail, A., Khalil, A., Zaatari, M., and El-Sabban, M.E. (2008). Heterocellular interaction enhances recruitment of alpha and beta-catenins and ZO-2 into functional gap-junction complexes and induces gap junction-dependant differentiation of mammary epithelial cells. Exp Cell Res 314, 3275-3291. WEB LINK
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