Replication, Population Dynamics, Genetics, & Evolution of Retroviruses

Oya Cingoz
Predoctoral Student
B.S. Bilkent University, Ankara, Turkey

Thesis Topic
Specificity of retroviral integration site selection.

Current Research
Integration of retroviral DNA into the host genome is an essential part of retroviral life cycle, with important consequences for both the virus and the host. The biochemistry of the integration reaction catalyzed by retroviral integrase is quite well-characterized. Despite the specificity of the integration reaction, host DNA sequences that serve as targets for integration do not show strict requirements. Although almost any sequence in the host genome could act as targets, integration seems to take place in a nonrandom fashion, with different retroviruses showing preferences at sites with various chromosomal features. I'm using an in vitro approach to understand target site selection by various retroviruses, including HIV, ALV and MLV.

1. Gupta PB, Proia D, Cingoz O, Weremowicz J, Naber SP, Weinberg RA, Kuperwasser C. Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers. Cancer Res. 2007 Mar 1;67(5):2062-71.