Replication, Population Dynamics, Genetics, & Evolution of Retroviruses

Coffin Laboratory


Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111

Lab (617) 636-0918
   

Patric Jern
Postdoctoral Fellow
Ph.D. Uppsala University, Sweden, Medical Virology
M.Sc. Uppsala University, Sweden, Molecular Biology

Thesis Title
Genomic Variation and Evolution of HERV-H and other Endogenous Retroviruses (ERVs)

Current Research
Genetic variation and evolution of endogenous and exogenous retroviruses.

Publications

  1. Benachenhou F, Jern P, Oja M, Sperber GO, Blikstad V, Somervuo P, Kaski S, and Blomberg J. 2009. Evolutionary Conservation of Orthoretroviral Long Terminal Repeats (LTRs) and ab initio Detection of Single LTRs in Genomic Data. PLoS ONE 4(4): e5179. Epub 2009 Apr 13.
  2. Jern P, Russell RA, Pathak VK, Coffin JM. 2009. Likely role of APOBEC3G- mediated G-to-A mutations in HIV-1 evolution and drug resistance. PLoS Pathog. 5(4):e1000367. Epub 2009 Apr 3.
  3. Jern P, Coffin JM. Host-retrovirus arms race: trimming the budget. Cell Host Microbe. 2008 Sep 11;4(3):196-7.
  4. Jern P., and Coffin J.M. Effects of Retroviruses on Human Genome Function. Annual Reviews in Genetics 2008 Aug 11.
  5. Jern P, Stoye JP, Coffin JM. Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses. PLoS Genet. 2007 Oct;3(10):2014-22. Epub 2007 Sep 10.
  6. Sperber GO, Airola T, Jern P, Blomberg J. Automated recognition of retroviral sequences in genomic data--RetroTector. Nucleic Acids Res. 2007;35(15):4964-76. Epub 2007 Jul 17.
  7. Jern P, Sperber GO, Blomberg J. Divergent patterns of recent retroviral integrations in the human and chimpanzee genomes: probable transmissions between other primates and chimpanzees. J Virol. 2006 Feb;80(3):1367-75.
  8. Jern P, Sperber GO, Blomberg J. Use of endogenous retroviral sequences (ERVs) and structural markers for retroviral phylogenetic inference and taxonomy. Retrovirology. 2005 Aug 10;2:50.
  9. Forsman A, Yun Z, Hu L, Uzhameckis D, Jern P, Blomberg J. Development of broadly targeted human endogenous gammaretroviral pol-based real time PCRs Quantitation of RNA expression in human tissues. J Virol Methods. 2005 Oct;129(1):16-30.
  10. Jern P, Sperber GO, Ahlsén G, Blomberg J. Sequence variability, gene structure, and expression of full-length human endogenous retrovirus H.
    J Virol. 2005 May;79(10):6325-37.