Principal Investigator
Ekaterina Heldwein
Assistant Professor
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Program Affiliations
Molecular Microbiology
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Contact Information
Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111
Office (617) 636-0858
Lab (617) 636-0474
Fax (617) 636-0337
Send Email |
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Selected Publications
Hannah B.P., Heldwein,
E.E., Bender F.C., Cohen, G.H., and Eisenberg,
R.J. (2007). Mutational Evidence of Internal Fusion
Loops in HSV glycoprotein B. J. Virol. 81,
4858-4865.
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Bender F.C., Samanta, M., Heldwein,
E.E., deLeon, M.P., Lou, H., Bilman, E.,
Whitbeck, J.C., Eisenberg, R.J., and Cohen, G.H.
(2007). Antigenic and mutational analyses of herpes
simplex virus glycoprotein B reveal four functional
regions. J. Virol. 81,
3827-3841.
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Heldwein
E.E., Lou, H., Bender,
F.C., Cohen, G.H., Eisenberg, R.J., and Harrison
S.C. (2006). Crystal structure of glycoprotein B
from Herpes Simplex Virus 1. Science 313, 217-220.
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Heldwein
E.E., Macia E., Wang
J., Yin H.L., Kirchhausen T.K., and Harrison S.C.
(2004). Crystal structure of the clathrin adaptor
AP-1 core. Proc. Natl. Acad.
Sci. USA 101, 14108-14113.
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Godsey M.H., Heldwein
E.E., and
Brennan R.G. (2002). Structural biology of bacterial
multidrug resistance gene regulators. J.
Biol. Chem. 277, 40169-40172.
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Heldwein
E.E. and Brennan R.G.
(2001). Crystal structure of the transcription activator
BmrR bound to DNA and a drug. Nature 409, 378-382.
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Zheleznova
E.E., Crosa J.H.,
and Brennan R.G. (2000). Characterization of DNA
and metal binding properties of Vibrio anguillarum
Fur. J. Bacteriol. 182, 6264-6267.
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Vazquez-Laslop N., Zheleznova
E.E., Markham P.N., Brennan R.G., and Neyfakh A.A.
(2000). Recognition of multiple drugs by a single
protein: a trivial solution of an old paradox. Biochem.
Soc. Trans. 28, 517-520.
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Jardim A., Liu W., Zheleznova
E., and Ullman B. (2000). Peroxisomal Targeting Signal-1
Receptor Protein PEX5 from Leishmania donovani. MOLECULAR,
BIOCHEMICAL, AND IMMUNOCYTOCHEMICAL CHARACTERIZATION.
J. Biol. Chem. 275, 13637-13644.
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Zheleznova
E.E., Markham P.N.,
Edgar R., Bibi E., Neyfakh A.A., and Brennan R.G.
(2000). A Structure-based Mechanism for Drug Binding
by Multidrug Transporters. TiBS 25, 39-43.
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Zheleznova
E.E., Markham P.N.,
Neyfakh A.A., and Brennan R.G. (1999). Structural
Basis of Multidrug Recognition by BmrR, a Transcription
Activator of a Multidrug Transporter. Cell 96, 353-362.
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Zheleznova
E.E., Markham P.N.,
Neyfakh A.A., and Brennan R.G. (1997). Preliminary
Structural Studies on the Multi-ligand Binding Domain
of the Transcription Activator, BmrR, from Bacillus
subtilis. Protein Science 6, 2465-2468.
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Schumacher M.A., Zheleznova
E.E.,
Poundstone K.S., Kluger R., Jones R.T., and Brennan
R.G. (1997). Allosteric Intermediates Indicate R2 is
the Liganded Hemoglobin End State. Proc.
Natl. Acad. Sci. USA 94, 7841-7844.
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Dement'eva E.I., Zheleznova
E.E.,
Kutuzova G.D., Lundovskih I.A., and Ugarova N.N. (1996).
Physicochemical Properties of Recombinant Luciferase
Luciola mingrelica and its Mutant Forms [Russian].
Biokhimiia 61, 152-159.
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